公开(公告)号：US20160304976A1

公开(公告)日：2016-10-20

申请号：US14914791

申请日：2014-08-28

申请人： THE UNIVERSITY OF TOKYO ,  NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE

发明人： Katsushi Tokunaga ,  Hiromi Sawai ,  Masashi Mizokami ,  Nao Nishida

IPC分类号： C12Q1/70

CPC分类号： C12Q1/706 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/172

摘要： An object of the present invention is to provide a method for detecting predisposition for chronicity of hepatitis B and/or the pathological progress, including an allele associated with chronicity of hepatitis B and/or the pathological progress. The above-described object is achieved by providing a method that includes a process of identifying alleles which are susceptible and resistant to chronicity of hepatitis B and/or the pathological progress in which a difference between a chronic hepatitis B patient group and a healthy control group is accurately reflected and comparing the alleles with base sequences or amino acid sequences corresponding to the alleles in a specimen; a process of analyzing whether bases of sites corresponding to the alleles in the base sequences of the specimen match bases of the alleles; and a process of specifying whether the hepatitis B of the specimen becomes chronic and/or the pathology is progressed, a method of performing inspection using the method, a reagent used for the method, and a test kit including the reagent.

摘要翻译： 本发明的目的是提供一种用于检测乙型肝炎长期易感性和/或病理进展的方法，包括与乙型肝炎的慢性相关的等位基因和/或病理进展。 上述目的通过提供一种方法来实现，该方法包括鉴定易感和耐乙型肝炎慢性的等位基因的过程和/或慢性乙型肝炎患者组与健康对照组之间的差异的病理进展 准确地反映并比较样品中与等位基因相对应的碱基序列或氨基酸序列等位基因; 分析与样本的碱基序列中的等位基因相对应的位点的碱基是否与等位基因的碱基相匹配的过程; 以及确定样本的乙型肝炎是否变慢和/或病变进行的方法，使用该方法进行检查的方法，用于该方法的试剂以及包含该试剂的检测试剂盒的处理。