公开(公告)号：US20230088546A1

公开(公告)日：2023-03-23

申请号：US17909054

申请日：2021-03-02

申请人： THERMALIN INC. ,  CASE WESTERN RESERVE UNIVERSITY

发明人： Michael A. WEISS ,  Mentor MULAJ ,  Laurie A. BROADWATER ,  Thomas HATTIER ,  Richard BERENSON

IPC分类号： A61K38/28 ,  A61K31/5578 ,  A61K31/194 ,  A61K31/198 ,  A61K33/42 ,  A61P3/10

摘要： A pharmaceutical composition comprises an effective amount of an insulin analogue comprising modified A-chain and B-chain polypeptides. The modified A chain comprises one or more substitutions relative to wild-type human insulin A-chain selected from a Gln, His or Glu substitution at position A8, a Glu or Ala substitution at position A14, and an Ala, Gln, Gly, or Thr substitution at position A21. The modified B-chain polypeptide comprises one or more modifications relative to wild-type human insulin B-chain selected from a deletion of the amino acid or amino acids at position B1, B1 and B2, or B1-B3, an Ala or Glu substitution at position B2, a Glu or Ala substitution at position B3, an Ala substitution at position B4; and a Glu or Lys substitution at position B29. The composition comprises one or more of iloprost, citrate, EDTA and a polyphosphate compound. The composition may be used to treat diabetes.