专利检索 ap:("THOMAS A. MUSTOE" OR "NICHOLAS M. DEAN" OR "MARK SISCO" OR "ZOL KRYGER" OR "C. FRANK BENNETT") AND inv:"ZOL KRYGER" 第 1 页

1.

发明申请
METHOD FOR REDUCING SCARRING DURING WOUND HEALING USING ANTISENSE COMPOUNDS DIRECTED TO CTGF 有权
标题翻译：使用抗CTGF的抗体化合物在伤口愈合过程中减少瘢痕形成的方法

公开(公告)号：US20110054004A1

公开(公告)日：2011-03-03

申请号：US12547481

申请日：2009-08-26

申请人： THOMAS A. MUSTOE , NICHOLAS M. DEAN , MARK SISCO , ZOL KRYGER , C. FRANK BENNETT

发明人： THOMAS A. MUSTOE , NICHOLAS M. DEAN , MARK SISCO , ZOL KRYGER , C. FRANK BENNETT

IPC分类号： A61K31/7088 , A61P17/02

CPC分类号： C12N15/1136 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/31 , C12N2310/3525

摘要： This invention provides a method for reducing hypertropic scarring resulting from dermal wound healing in a subject in need which comprises administering to the subject an antisense oligonucleotide which inhibits expression of connective tissue growth factor (CTGF) in an amount effective to inhibit expression of CTGF and thereby reduce hypertrophic scarring.

摘要翻译： 本发明提供一种在需要的受试者中减少由真皮伤口愈合引起的高血压瘢痕形成的方法，其包括以有效抑制CTGF表达的量向受试者施用抑制结缔组织生长因子（CTGF）表达的反义寡核苷酸，从而减少肥厚性瘢痕。