公开(公告)号：US20150164803A1

公开(公告)日：2015-06-18

申请号：US14631353

申请日：2015-02-25

Applicant: TODA KOGYO CORPORATION

Inventor： Toshiyuki HAKATA ,  Tomoko OKITA

IPC: A61K9/16 ,  A61K49/04 ,  A61K49/18

CPC classification number: C09C1/24 ,  A61K41/0052 ,  A61K47/6923 ,  A61K47/6929 ,  A61K49/0002 ,  A61K49/0428 ,  A61K49/1854 ,  B82Y5/00 ,  B82Y30/00 ,  C01G49/0036 ,  C01G49/08 ,  C01P2004/64 ,  C01P2004/80 ,  C01P2006/12 ,  C01P2006/42

Abstract: The present invention relates to a magnetic particle-containing water dispersion wherein the magnetic particles have a primary particle diameter of 5 to 15 nm and an average secondary particle diameter of 10 to 60 nm, and the water dispersion has a zeta potential of not more than −20 mV when a pH value of the water dispersion lies within the range of 6 to 8, and further a surface of the respective magnetic particles is coated with a carboxyl group-containing polymer. The magnetic particle-containing water dispersion is produced by heating an aqueous solution in which the carboxyl group-containing polymer is dissolved, to a temperature of 90 to 100° C. in a nitrogen atmosphere; adding a solution of a ferrous (II) salt and a ferric (III) salt and an alkali solution to the aqueous solution to react with each other at the same temperature; adding ethanol to the solution to obtain a precipitate; and removing a supernatant liquid from the solution, and then dispersing the precipitate in water and subjecting the resulting dispersion to dialysis. The magnetic particle-containing water dispersion is useful as a magnetic particle-containing water dispersion capable of producing magnetic particle-containing drugs for diagnosis and therapies which can exhibit a uniform functionality, with a good reproducibility.

Abstract translation: 本发明涉及一种含磁性颗粒的水分散体，其中磁性颗粒的初级粒径为5〜15nm，平均二次粒径为10〜60nm，水分散体的ζ电位不大于 当水分散体的pH值在6至8的范围内时，-20mV，并且进一步用含羧基的聚合物涂覆各个磁性颗粒的表面。 通过将含有羧基的聚合物溶解的水溶液在氮气气氛中加热至90〜100℃，制成含有磁性颗粒的水分散体; 在水溶液中加入亚铁（II）盐和三价铁（III）盐和碱溶液的溶液在相同温度下相互反应; 向溶液中加入乙醇以得到沉淀物; 从溶液中除去上清液，然后将沉淀物分散在水中，使得到的分散体透析。 含有磁性颗粒的水分散体可用作能够产生含有磁性颗粒的药物用于诊断和治疗的含磁性颗粒的水分散体，其可以显示均匀的官能度，具有良好的再现性。

公开(公告)号：US20160164086A1

公开(公告)日：2016-06-09

申请号：US15019322

申请日：2016-02-09

Applicant: TODA KOGYO CORPORATION

Inventor： Akinori YAMAMOTO ,  Tomoko OKITA ,  Hiroshi YAMAMOTO ,  Kohji MORI ,  Kazumichi KOGA ,  Akihisa KAJIYAMA

IPC: H01M4/485 ,  C01G23/00 ,  H01M10/0525

CPC classification number: H01M4/485 ,  C01G23/005 ,  C01G23/006 ,  C01P2002/32 ,  C01P2002/60 ,  C01P2002/70 ,  C01P2002/72 ,  C01P2002/76 ,  C01P2002/77 ,  C01P2004/03 ,  C01P2004/80 ,  C01P2006/12 ,  C01P2006/40 ,  H01B1/08 ,  H01M10/0525 ,  H01M2004/027 ,  Y02E60/122 ,  Y02P70/54

Abstract: According to the present invention, there are provided lithium titanate particles which exhibit an excellent initial discharge capacity and an enhanced high-efficiency discharge capacity retention rate as an active substance for non-aqueous electrolyte secondary batteries and a process for producing the lithium titanate particles, and Mg-containing lithium titanate particles.

Abstract translation: 根据本发明，提供了作为非水电解质二次电池的活性物质，具有优异的初始放电容量和提高的高效率放电容量保持率的钛酸锂颗粒和钛酸锂颗粒的制造方法， 和含Mg的钛酸锂颗粒。