公开(公告)号：US20240307351A1

公开(公告)日：2024-09-19

申请号：US18539931

申请日：2023-12-14

申请人： TOHOKU UNIVERSITY

发明人： Takaaki Abe ,  Shin-ichiro Kanno ,  Takehiro Suzuki ,  Ko Hashimoto ,  Tomoko Kasahara ,  Fumika Nanto-Hara

IPC分类号： A61K31/405 ,  A61K31/454 ,  A61P1/16 ,  A61P3/04

CPC分类号： A61K31/405 ,  A61K31/454 ,  A61P1/16 ,  A61P3/04

摘要： It is to provide an agent for anti-aging or cellular rejuvenation, and an agent for preventing or ameliorating symptoms or diseases associated with aging, in which a low-molecular compound that can be produced relatively simply and inexpensively is contained as an active ingredient.
Provided are an agent for anti-aging or cellular rejuvenation and a preventive or ameliorative agent for a symptom or disease associated with aging. Such agents contain one or more compounds selected from the group consisting of a compound represented by General Formula (I0), a compound represented by General Formula (II), a compound represented by General Formula (III) and pharmaceutically acceptable salts thereof when R3 is OH.

公开(公告)号：US20240270692A1

公开(公告)日：2024-08-15

申请号：US18433832

申请日：2024-02-06

申请人： TOHOKU UNIVERSITY

发明人： Takaaki ABE ,  Yotaro Matsumoto ,  Takehiro Suzuki ,  Ryota Kujirai ,  Atsushi Higashitani ,  Takeya Sato ,  Eunsang Kwon

IPC分类号： C07D209/18 ,  A61K31/405 ,  A61K47/02 ,  A61K47/10 ,  A61P27/16

CPC分类号： C07D209/18 ,  A61K31/405 ,  A61K47/02 ,  A61K47/10 ,  A61P27/16

摘要： An S(+) form of 4-(2,4-difluorophenyl)-2-(1H-indol-3-yl)-4-oxo-butanoic acid or a physiologically acceptable salt thereof may be useful as an active ingredient of a pharmaceutical composition or a food or drink composition, and the like. An enantiomeric excess of an S(+) form may be at least 97% or more. The compound may be used in treating, improving, or preventing a mitochondrial disease and/or a symptom or a disease associated with aging.