公开(公告)号：US11707530B2

公开(公告)日：2023-07-25

申请号：US16326657

申请日：2017-08-17

Applicant: TOKYO INSTITUTE OF TECHNOLOGY ,  OSAKA UNIVERSITY

Inventor： Nobuhiro Nishiyama ,  Hiroyasu Takemoto ,  Takahiro Nomoto ,  Keishiro Tomoda ,  Makoto Matsui ,  Naoki Yamada ,  Yuto Honda ,  Hideshi Ishii ,  Masaki Mori ,  Masamitsu Konno

IPC: A61K47/64 ,  A61K49/14

CPC classification number: A61K47/6455 ,  A61K49/146

Abstract: The present invention pertains to a ligand that contains a plurality of groups represented by formula (1) and is capable of multivalently binding to a glutamine transporter expressed in excess in a cancer cell compared to a normal cell.

公开(公告)号：US20210308271A1

公开(公告)日：2021-10-07

申请号：US16326657

申请日：2017-08-17

Applicant: TOKYO INSTITUTE OF TECHNOLOGY ,  OSAKA UNIVERSITY

Inventor： Nobuhiro Nishiyama ,  Hiroyasu Takemoto ,  Takahiro Nomoto ,  Keishiro Tomoda ,  Makoto Matsui ,  Naoki Yamada ,  Yuto Honda ,  Hideshi Ishii ,  Masaki Mori ,  Masamitsu Konno

IPC: A61K47/64 ,  A61K49/14

Abstract: The present invention pertains to a ligand that contains a plurality of groups represented by formula (1) and is capable of multivalently binding to a glutamine transporter expressed in excess in a cancer cell compared to a normal cell.

公开(公告)号：US20220265836A1

公开(公告)日：2022-08-25

申请号：US17613912

申请日：2020-05-29

Applicant: TOKYO INSTITUTE OF TECHNOLOGY ,  KAWASAKI INSTITUTE OF INDUSTRIAL PROMOTION

Inventor： Nobuhiro Nishiyama ,  Yuto Honda ,  Takahiro Nomoto ,  Hiroyasu Takemoto ,  Makoto Matsui ,  Hiroaki Kinoh ,  Kazunori Kataoka ,  Xueying Liu ,  Anjaneyulu Dirisala

IPC: A61K47/64 ,  A61K47/69 ,  A61K47/59 ,  A61K47/54 ,  A61K47/60 ,  A61P35/00

Abstract: A complex is provided comprising a conjugate in which a polymer having a boronic acid group and a compound having a diol structure are bonded, and a substance that is complexed with the conjugate.