公开(公告)号：US20210387194A1

公开(公告)日：2021-12-16

申请号：US17458642

申请日：2021-08-27

Applicant: TOPPAN PRINTING CO., LTD.

Inventor： Keisuke GOTO ,  Yoichi MAKINO

IPC: B01L3/00 ,  G01N21/64

Abstract: A microfluidic device including a substrate having at least one droplet holder formed thereon, and a cover member facing the substrate with a space between the cover member and the substrate, and having a flow path formed in the space and connected to the droplet holder. The flow path has a height of more than 0 μm and 30 μm or less.

公开(公告)号：US20200003691A1

公开(公告)日：2020-01-02

申请号：US16570628

申请日：2019-09-13

Applicant: TOPPAN PRINTING CO., LTD.

Inventor： Misaki NAGAHARA ,  Yoichi MAKINO ,  Akihiro HOSHINO ,  Takumi HIRASE ,  Tomoko KUNITOMI ,  Keisuke GOTO ,  Yusuke HORIUCHI

IPC: G01N21/64 ,  B01L3/00 ,  G01N21/76 ,  C12Q1/6825

Abstract: A device including a well array including wells in which a target substance is detected based on a biochemical reaction thereof. Each of the wells has an aspect ratio of 1 or more as calculated by Formula (1) such that the biochemical reaction of the target substance is detected, Aspect ratio=Depth of each well/Diameter of largest circle among circles included in a region enclosed by a rim of each well  Formula (1).

公开(公告)号：US20210394185A1

公开(公告)日：2021-12-23

申请号：US17464114

申请日：2021-09-01

Applicant: TOPPAN PRINTING CO., LTD.

Inventor： Keisuke GOTO ,  Yoichi MAKINO ,  Yuta SUZUKI

IPC: B01L3/00

Abstract: A microfluidic device including a microwell array having microwells, and a cover member facing the microwell array with a gap between the cover member and the microwell array, and having a flow path formed in the gap. The cover member has a surface facing the microwell array, and the surface has an arithmetic average roughness Ra of 70 nm or less.

公开(公告)号：US20190060897A1

公开(公告)日：2019-02-28

申请号：US16173102

申请日：2018-10-29

Applicant: TOPPAN PRINTING CO., LTD.

Inventor： Yoichi MAKINO ,  Akihiro HOSHINO ,  Tomoko KUNITOMI ,  Keisuke GOTO ,  Yosuke HORIUCHI

IPC: B01L3/00 ,  G01N21/64

Abstract: An analysis apparatus including a stage, an analysis device placed on the stage and including receiving sections which accommodate a sample and a reagent for biochemical reaction, and are communicated with one another through a flow path having an inlet and an outlet, a liquid introduction section which is connected to the inlet and supplies into the flow path the sample, the reagent, and an sealing liquid for sealing each of the receiving sections, and a waste liquid storage section which is connected to the outlet and stores as waste liquid an excess of the sample and the reagent and a part of the sealing liquid supplied to the flow path, an optical system which includes an objective lens, emits excitation light to the receiving sections and allows observation of fluorescence generated in the receiving sections by the excitation light, and a control unit that controls such that the sealing liquid and the excess of the sample and the reagent form an interface in the waste liquid storage section, and that the interface is formed at a distance not less than a fluorescence-obtainable distance from a bottom of the receiving sections.