公开(公告)号：US20240239851A1

公开(公告)日：2024-07-18

申请号：US18514761

申请日：2023-11-20

Applicant: TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Maria PELLEGRINI ,  Adam H. BARCZEWSKI ,  Gevorg GRIGORYAN

IPC: C07K14/47

CPC classification number: C07K14/4703

Abstract: The present disclosure relates to a modified NEMO protein that, inter alia, allows for structural determination of the NEMO protein in the apo-form and in complex with a ligand by NMR or X-ray crystallography. The present disclosure also relates to the use of such modified NEMO proteins to screen and validate inhibitors of the interaction between NEMO and IKKα and/or IKKβ and for structure determination of NEMO in the apo-form and in complex with a ligand, preferably by NMR or X-ray crystallography.