公开(公告)号：US20100105636A1

公开(公告)日：2010-04-29

申请号：US12651849

申请日：2010-01-04

申请人： Taiji FURUKAWA ,  Osamu Yamada ,  Hiroo Matsumoto ,  Toru Yamashita ,  Yukinori Masuda

发明人： Taiji FURUKAWA ,  Osamu Yamada ,  Hiroo Matsumoto ,  Toru Yamashita ,  Yukinori Masuda

IPC分类号： A61K31/675 ,  A61K31/551 ,  A61K31/4545

CPC分类号： A61K31/675

摘要： There is provided a T-type calcium channel blocker that is a compound of formula (1), a pharmaceutically acceptable salt thereof or a solvate thereof: wherein Ar1 is phenyl group, pyridyl group, furyl group or 2,1,3-benzoxadiazol-4-yl group; nitrogen-containing hetero ring moiety is 1,4-dihydropyridine ring or pyridine ring; Z is a group of formula (2) or CO2R2; Ra and Rb are independently of each other C1-6alkyl group, ANR8R9, CH2OANR8R9, or the like; in case where the nitrogen-containing hetero ring moiety is 1,4-dihydropyridine ring, R1 is C1-6alkyl group, ANR8R9, AN(CH2CH2)2NR8, AN(CH2CH2)2O, AOR8 or benzyl group; R3 is hydrogen atom, C1-20alkyl group, ANR8R9, a group of formula or the like.

摘要翻译： 提供了式（1）化合物，其药学上可接受的盐或其溶剂化物的T型钙通道阻断剂：其中Ar1是苯基，吡啶基，呋喃基或2,1,3-苯并恶二唑-2-基， 4-基; 含氮杂环部分为1,4-二氢吡啶环或吡啶环; Z是式（2）或CO 2 R 2的基团; R a和R b彼此独立地为C 1-6烷基，ANR 8 R 9，CH 2 OANR 8 R 9等; 在含氮杂环部分为1,4-二氢吡啶环的情况下，R 1为C 1-6烷基，ANR 8 R 9，AN（CH 2 CH 2）2 NR 8，AN（CH 2 CH 2）2 O，AOR 8或苄基; R3是氢原子，C1-20烷基，ANR8R9，式等基团。