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1.发明申请公开(公告)号：US20100016547A1
公开(公告)日：2010-01-21
申请号：US12085770
申请日：2006-11-29
申请人： Takaomi Ito , Akio Takimoto , Hirofumi Nagatome , Masataka Fumoto , Taichi Ueda , Shin-Ichiro Nishimura
发明人： Takaomi Ito , Akio Takimoto , Hirofumi Nagatome , Masataka Fumoto , Taichi Ueda , Shin-Ichiro Nishimura
IPC分类号： C07K14/605
CPC分类号： C07K14/605 , A61K38/00 , C08B37/006
摘要： The present invention related to providing a novel medicine for treating diabetes. It is possible to provide a GLP-1 derivative which is resistant to enzyme degradation by glycosylation of the peptide side chain.
摘要翻译： 本发明涉及提供一种治疗糖尿病的新型药物。 可以提供通过肽侧链的糖基化对酶降解具有抗性的GLP-1衍生物。
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公开(公告)号：US08414778B2
公开(公告)日：2013-04-09
申请号：US11920707
申请日：2006-05-17
IPC分类号： B01D37/04
CPC分类号： B01L3/0275 , B01D61/145 , B01L2300/0681 , G01N2035/1053
摘要： The present invention relates to a filtration method, a filter-incorporated tip and a filtration device, and its object is to perform efficient and swift isolation of a target substance. The filtration method therefore comprises: a liquid introducing step to introduce a liquid into a filter-incorporated tip through a guide opening portion thereof, wherein the filter-incorporated tip has a nozzle-tipped container and a filter, the nozzle-tipped container has a guide opening portion that can be directly or indirectly fitted to an air nozzle capable of ejecting a gas and a front nozzle portion capable of delivering the liquid by the ejection of the gas from the air nozzle, and the filter is locked in the nozzle-tipped container to partition the interior of the nozzle-tipped container into the guide opening portion side and the front nozzle portion side and is adapted to temporarily hold the liquid and isolate a predetermined substance as the liquid passes through the filter, with the nozzle-tipped container coupled to the air nozzle on the guide opening portion side; a coupling step to directly or indirectly couple the filter-incorporated tip containing the liquid to the air nozzle; and a pressure application step to eject the gas from the air nozzle into the coupled filter-incorporated tip.
摘要翻译： 本发明涉及一种过滤方法，一种过滤器引入端和一种过滤装置，其目的是对目标物质进行高效快速的分离。 因此，过滤方法包括：液体引入步骤，用于通过其引导开口部分将液体引入到过滤器引入的尖端中，其中过滤器引入的尖端具有喷嘴顶端的容器和过滤器，喷嘴端的容器具有 导向开口部分，其可以直接或间接地装配到能够喷射气体的空气喷嘴和通过从空气喷嘴喷射气体而能够输送液体的前喷嘴部分，并且过滤器被锁定在喷嘴尖端 容器将喷嘴头容器的内部分隔成导向开口部分侧和前部喷嘴部分侧，并且当液体通过过滤器时，适于临时保持液体并隔离预定物质，喷嘴头容器 与导向开口部侧的空气喷嘴连接; 将包含液体的过滤器引入的尖端直接或间接地耦合到空气喷嘴的耦合步骤; 以及压力施加步骤，用于将气体从空气喷嘴喷射到耦合的过滤器引入的尖端中。
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公开(公告)号：US20090294385A1
公开(公告)日：2009-12-03
申请号：US11920707
申请日：2006-05-17
CPC分类号： B01L3/0275 , B01D61/145 , B01L2300/0681 , G01N2035/1053
摘要： The present invention relates to a filtration method, a filter-incorporated tip and a filtration device, and its object is to perform efficient and swift isolation of a target substance. The filtration method therefore comprises: a liquid introducing step to introduce a liquid into a filter-incorporated tip through a guide opening portion thereof, wherein the filter-incorporated tip has a nozzle-tipped container and a filter, the nozzle-tipped container has a guide opening portion that can be directly or indirectly fitted to an air nozzle capable of ejecting a gas and a front nozzle portion capable of delivering the liquid by the ejection of the gas from the air nozzle, and the filter is locked in the nozzle-tipped container to partition the interior of the nozzle-tipped container into the guide opening portion side and the front nozzle portion side and is adapted to temporarily hold the liquid and isolate a predetermined substance as the liquid passes through the filter, with the nozzle-tipped container coupled to the air nozzle on the guide opening portion side; a coupling step to directly or indirectly couple the filter-incorporated tip containing the liquid to the air nozzle; and a pressure application step to eject the gas from the air nozzle into the coupled filterincorporated tip.
摘要翻译： 本发明涉及一种过滤方法，一种过滤器引入端和一种过滤装置，其目的是对目标物质进行高效快速的分离。 因此，过滤方法包括：液体引入步骤，用于通过其引导开口部分将液体引入到过滤器引入的尖端中，其中过滤器引入的尖端具有喷嘴顶端的容器和过滤器，喷嘴端的容器具有 导向开口部分，其可以直接或间接地装配到能够喷射气体的空气喷嘴和通过从空气喷嘴喷射气体而能够输送液体的前喷嘴部分，并且过滤器被锁定在喷嘴尖端 容器将喷嘴头容器的内部分隔成导向开口部分侧和前部喷嘴部分侧，并且当液体通过过滤器时，适于临时保持液体并隔离预定物质，喷嘴头容器 与导向开口部侧的空气喷嘴连接; 将包含液体的过滤器引入的尖端直接或间接地耦合到空气喷嘴的耦合步骤; 以及压力施加步骤，用于将气体从空气喷嘴喷射到耦合的过滤器组合的尖端中。
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4.发明申请Process for synthesis of mucin-type peptides and muc1-related glycopeptides 审中-公开用于合成粘蛋白型肽和muc1相关糖肽的方法公开(公告)号：US20090263858A1
公开(公告)日：2009-10-22
申请号：US11663081
申请日：2005-09-14
CPC分类号： C12P21/005 , C07K14/4727 , C12P21/06
摘要： The invention aims at providing novel compounds useful as primer in producing mucin-type glycopeptides which are useful in a wide field including materials for biochemical research, drugs, and food and the production of which was difficult in the prior art; and a process for the production of glycopeptides by using the primers. The aim is attained by providing novel glycopeptide derivatives (represented by the general formula (I)) which each bear an aldehyde or ketone group at the end and each contain an amino acid residue cleavable with a protease; and an easy and simple process for the production of glycopeptides by using the derivative as the primer.
摘要翻译： 本发明旨在提供可用作生产粘蛋白型糖肽的引物的新化合物，其可用于广泛的领域，包括用于生物化学研究，药物和食品的材料，并且其生产在现有技术中是困难的; 以及通过使用引物生产糖肽的方法。 目的是通过提供新的糖肽衍生物（由通式（I）表示），其末端具有醛基或酮基，并且各自含有可用蛋白酶切割的氨基酸残基; 以及通过使用该衍生物作为引物制备糖肽的简单和简单的方法。
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公开(公告)号：US07612225B2
公开(公告)日：2009-11-03
申请号：US10592540
申请日：2005-03-24
申请人： Masataka Fumoto
发明人： Masataka Fumoto
IPC分类号： C07C229/00
CPC分类号： C07C231/22 , A61K31/216 , C07J63/008 , C07C233/55
摘要： Disclosed herein are a novel crystal of a novel triterpene derivative, a method for producing the crystals, and a pharmaceutical preparation obtained by using the crystals.The novel crystal is a crystal of a compound (I) of the formula (I):
摘要翻译： 本文公开了新型三萜衍生物的新晶体，晶体的制造方法以及使用该晶体得到的药物制剂。 新颖的晶体是式（I）的化合物（I）的晶体：
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公开(公告)号：US20070282126A1
公开(公告)日：2007-12-06
申请号：US10592540
申请日：2005-03-24
申请人： Masataka Fumoto
发明人： Masataka Fumoto
IPC分类号： C07C233/55
CPC分类号： C07C231/22 , A61K31/216 , C07J63/008 , C07C233/55
摘要： Disclosed herein are a novel crystal of a novel triterpene derivative, a method for producing the crystals, and a pharmaceutical preparation obtained by using the crystals. The novel crystal is a crystal of a compound (I) of the formula (I):
摘要翻译： 本文公开了新型三萜衍生物的新晶体，晶体的制造方法以及使用该晶体得到的药物制剂。 新颖的晶体是式（I）的化合物（I）的晶体：
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