公开(公告)号：US08609746B2

公开(公告)日：2013-12-17

申请号：US13203221

申请日：2010-02-23

申请人： Takashi Nakamura ,  Koji Goto ,  Takehiro Shibuya ,  Yoshimichi Ueda ,  Tokuo Suita ,  Masashi Imamura ,  Hiroaki Nishii

发明人： Takashi Nakamura ,  Koji Goto ,  Takehiro Shibuya ,  Yoshimichi Ueda ,  Tokuo Suita ,  Masashi Imamura ,  Hiroaki Nishii

IPC分类号： A61F2/28 ,  A61K6/083 ,  C08L33/12 ,  C08K3/22

CPC分类号： A61L24/0089 ,  A61L24/06 ,  A61L2430/02 ,  C08L33/06

摘要： A bone cement composition which contains large-diameter (meth)acrylate polymer particles having an average particle diameter of 10 to 60 μm, small-diameter (meth)acrylate polymer particles having an average particle diameter of 0.1 to 2.0 μm, a (meth)acrylate monomer and a polymerization initiator, wherein the content of the small-diameter (meth)acrylate polymer particles is 5 to 30% by mass based on the total mass of the small-diameter (meth)acrylate polymer particles and the large-diameter (meth)acrylate polymer particles, and a part or a whole of the small-diameter (meth)acrylate polymer particles are contained in the form of aggregates having an average particle diameter of 30 to 50 μm.

摘要翻译： 一种骨水泥组合物，其含有平均粒径为10〜60μm的大直径（甲基）丙烯酸酯聚合物粒子，平均粒径为0.1〜2.0μm的小直径（甲基）丙烯酸酯聚合物粒子，（甲基） 丙烯酸酯单体和聚合引发剂，其中小直径（甲基）丙烯酸酯聚合物颗粒的含量相对于小直径（甲基）丙烯酸酯聚合物颗粒和大直径（甲基）丙烯酸酯聚合物颗粒的总质量为5〜30质量％ 甲基）丙烯酸酯聚合物颗粒，一部分或全部小直径（甲基）丙烯酸酯聚合物颗粒以平均粒径为30至50微米的聚集体的形式包含。

公开(公告)号：US20120035296A1

公开(公告)日：2012-02-09

申请号：US13203221

申请日：2010-02-23

申请人： Takashi Nakamura ,  Koji Goto ,  Takehiro Shibuya ,  Yoshimichi Ueda ,  Tokuo Suita ,  Masashi Imamura ,  Hiroaki Nishii

发明人： Takashi Nakamura ,  Koji Goto ,  Takehiro Shibuya ,  Yoshimichi Ueda ,  Tokuo Suita ,  Masashi Imamura ,  Hiroaki Nishii

IPC分类号： A61K47/02 ,  C08L33/10

CPC分类号： A61L24/0089 ,  A61L24/06 ,  A61L2430/02 ,  C08L33/06

摘要： The invention has as its objects the provision of a bone cement composition, a bone cement composition kit for obtaining the bone cement composition, and a production method of a bone cement hardened material, which are short in doughing time that is a time required to become a state in which a good handling operation can be conducted, and have consequently capable of achieving a high working efficiency by shortening the time required before the handling operation is started.The bone cement composition of the invention contains large-diameter (meth)acrylate polymer particles having an average particle diameter of 10 to 60 μm, small-diameter (meth)acrylate polymer particles having an average particle diameter of 0.1 to 2.0 μm, a (meth)acrylate monomer and a polymerization initiator, wherein the content of the small-diameter (meth)acrylate polymer particles is 5 to 30% by mass based on the total mass of the small-diameter (meth)acrylate polymer particles and the large-diameter (meth)acrylate polymer particles.

摘要翻译： 本发明的目的是提供一种骨水泥组合物，用于获得骨水泥组合物的骨水泥组合物试剂盒和骨水泥硬化材料的制造方法，其在加热时间短，是成为 能够进行良好的操作操作的状态，因此能够通过缩短开始处理操作之前所需的时间来实现高工作效率。 本发明的骨水泥组合物含有平均粒径为10〜60μm的大直径（甲基）丙烯酸酯聚合物粒子，平均粒径为0.1〜2.0μm的小直径（甲基）丙烯酸酯聚合物粒子，（ （甲基）丙烯酸酯单体和聚合引发剂，其中小直径（甲基）丙烯酸酯聚合物颗粒的含量相对于小直径（甲基）丙烯酸酯聚合物颗粒的总质量为5〜30质量％ （甲基）丙烯酸酯聚合物颗粒。

公开(公告)号：US20120046385A1

公开(公告)日：2012-02-23

申请号：US13202850

申请日：2010-02-23

申请人： Takashi Nakamura ,  Koji Goto ,  Takehiro Shibuya ,  Yoshimichi Ueda ,  Tokuo Suita ,  Hiroaki Nishii

发明人： Takashi Nakamura ,  Koji Goto ,  Takehiro Shibuya ,  Yoshimichi Ueda ,  Tokuo Suita ,  Hiroaki Nishii

IPC分类号： A61L24/06

CPC分类号： A61L24/0089 ,  A61L27/446 ,  A61L2430/02 ,  C08L33/10

摘要： The invention has as its objects the provision of a bone cement composition and a bone cement composition kit for obtaining the bone cement composition having bioactivity and capable of forming a hardened material having high mechanical strength practically required, and the provision of a bone cement formed material having both bioactivity and high mechanical strength practically required and a production method thereof.The bone cement composition of the invention contains titanium dioxide particles having a median diameter of 0.5 to 7.0 μm as measured by a laser diffraction/scattering type particle size distribution analyzer and a BET specific surface area of 0.5 to 7.0 m2/g as measured by a nitrogen adsorption method, and a base-forming component comprising a (meth)acrylate polymer and a (meth)acrylate monomer, wherein the content of the titanium dioxide particles is 5 to 50% by mass based on the total mass of the composition.

摘要翻译： 本发明的目的是提供一种骨水泥组合物和骨水泥组合物试剂盒，用于获得具有生物活性的骨水泥组合物，并且能够形成具有实际需要的高机械强度的硬化材料，并且提供骨水泥成形材料 具有生物活性和实际需要的高机械强度及其制造方法。 本发明的骨水泥组合物含有通过激光衍射/散射型粒度分布分析仪测定的中值粒径为0.5〜7.0μm，BET比表面积为0.5〜7.0m 2 / g的二氧化钛粒子， 氮气吸附法和含有（甲基）丙烯酸酯系聚合物和（甲基）丙烯酸酯单体的基材形成成分，其中，相对于组合物的总质量，二氧化钛粒子的含量为5〜50质量％。

公开(公告)号：US08658713B2

公开(公告)日：2014-02-25

申请号：US13202850

申请日：2010-02-23

申请人： Takashi Nakamura ,  Koji Goto ,  Takehiro Shibuya ,  Yoshimichi Ueda ,  Tokuo Suita ,  Hiroaki Nishii

发明人： Takashi Nakamura ,  Koji Goto ,  Takehiro Shibuya ,  Yoshimichi Ueda ,  Tokuo Suita ,  Hiroaki Nishii

IPC分类号： A61F2/28 ,  C08K3/22

CPC分类号： A61L24/0089 ,  A61L27/446 ,  A61L2430/02 ,  C08L33/10

摘要： A bone cement composition which contains titanium dioxide particles having a median diameter of 0.5 to 7.0 μm as measured by a laser diffraction/scattering particle size distribution analyzer and a BET specific surface area of 0.5 to 7.0 m2/g as measured by a nitrogen adsorption method, and a base-forming component comprising a (meth)acrylate polymer and a (meth)acrylate monomer, wherein the content of the titanium dioxide particles is 5 to 50% by mass based on the total mass of the composition. The bone cement composition has bioactivity and is capable of forming a hardened material having a high mechanical strength.

摘要翻译： 一种骨水泥组合物，其含有通过激光衍射/散射粒度分布分析仪测定的中值粒径为0.5〜7.0μm的二氧化钛粒子，并且通过氮吸附法测定的BET比表面积为0.5〜7.0m 2 / g ，和包含（甲基）丙烯酸酯聚合物和（甲基）丙烯酸酯单体的基底形成组分，其中二氧化钛颗粒的含量相对于组合物的总质量为5〜50质量％。 骨水泥组合物具有生物活性并且能够形成具有高机械强度的硬化材料。