公开(公告)号：US20150045349A1

公开(公告)日：2015-02-12

申请号：US14379343

申请日：2013-02-19

申请人： Takeda Pharmaceutical Company Limited

发明人： Hiroyuki Nagamiya ,  Masato Yoshida ,  Masaki Seto ,  Shogo Marui ,  Tsuneo Oda ,  Yuji Ishichi ,  Hideo Suzuki ,  Tomokazu Kusumoto ,  Takatoshi Yogo ,  Chul Yun Rhim ,  Cheolhwan Yoon ,  Gil Nam Lee ,  Hyun Bin Kang ,  Kwang Ok Kim ,  Hye Sun Jeon

IPC分类号： C07D471/04

CPC分类号： C07D471/04 ,  C07D519/00

摘要： The present invention provides an agent for the prophylaxis or treatment of autoimmune diseases (e.g., psoriasis, rheumatoid arthritis, inflammatory bowel disease, Sjogren's syndrome, Behcet's disease, multiple sclerosis, systemic lupus erythematosus etc.) and the like, which has a superior Tyk2 inhibitory action.The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：US09085578B2

公开(公告)日：2015-07-21

申请号：US14379343

申请日：2013-02-19

申请人： Takeda Pharmaceutical Company Limited

发明人： Hiroyuki Nagamiya ,  Masato Yoshida ,  Masaki Seto ,  Shogo Marui ,  Tsuneo Oda ,  Yuji Ishichi ,  Hideo Suzuki ,  Tomokazu Kusumoto ,  Takatoshi Yogo ,  Chul Yun Rhim ,  Cheolhwan Yoon ,  Gil Nam Lee ,  Hyun Bin Kang ,  Kwang Ok Kim ,  Hye Sun Jeon

IPC分类号： C07D401/14 ,  A61K31/437 ,  C07D471/04 ,  C07D519/00

CPC分类号： C07D471/04 ,  C07D519/00

摘要： The present invention provides an agent for the prophylaxis or treatment of autoimmune diseases (e.g., psoriasis, rheumatoid arthritis, inflammatory bowel disease, Sjogren's syndrome, Behcet's disease, multiple sclerosis, systemic lupus erythematosus etc.) and the like, which has a superior Tyk2 inhibitory action.The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.

摘要翻译： 本发明提供了一种用于预防或治疗自身免疫性疾病（例如牛皮癣，类风湿性关节炎，炎性肠病，干燥综合征，白塞病，多发性硬化，系统性红斑狼疮等）等，其具有优异的Tyk2 抑制作用。 本发明涉及由下式表示的化合物，其中每个符号如说明书中所定义，或其盐。