公开(公告)号：US20240228437A1

公开(公告)日：2024-07-11

申请号：US18557255

申请日：2022-04-25

申请人： Takeda Pharmaceutical Limited Company

发明人： Masatoshi YAMADA ,  Sayuri HIRANO ,  Osamu YABE ,  Yuichi KAJITA ,  Tsuneo ODA ,  Takashi ABE ,  Hironori YAMASHITA

IPC分类号： C07D207/14

CPC分类号： C07D207/14

摘要： The present invention provides a method suitable for industrial production of a compound of formula (V): (V) comprising a step of subjecting a compound (IV) to an asymmetric reductive amination reaction in the presence of a metal complex comprising a chiral ligand and subjecting this product to purification using salt formation with N-(4-methylbenzene-1-sulfonyl)-L-phenylalanine.