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31 条记录 (耗时 0.018 秒)

    Intrauterine system embracing selected copolymeric membranes for administering beneficial agent
    1.
    发明授权
    Intrauterine system embracing selected copolymeric membranes for administering beneficial agent 失效
    子宫内系统包含用于施用有益剂的选择的共聚膜

    公开(公告)号：US4188951A

    公开(公告)日：1980-02-19

    申请号：US826928

    申请日：1977-08-22

    申请人： Takeru Higuchi ,  Anwar A. Hussain

    发明人： Takeru Higuchi ,  Anwar A. Hussain

    IPC分类号： A61F6/14 ,  A61K9/00 ,  A61K9/70 ,  A61M31/00 ,  A61M7/00

    CPC分类号： A61M31/002 ,  A61F6/14 ,  A61F6/142 ,  A61K9/0039 ,  A61K9/0092

    摘要： An intrauterine system for releasing beneficial agent to the uterus at a controlled and continuous rate for a prolonged period of time is disclosed. The system is shaped, sized and adapted for insertion and retention in the uterus. The system contains a beneficial agent and it is formed of a copolymeric material permeable to the passage of agent by diffusion. The material is an ethylene-vinyl ester polymer of the general formula: ##STR1## wherein R is hydrogen, alkyl of 2 to 7 carbons, or aryl, m is (4 to 80)% by weight and n is (100-m)% by weight.

    摘要翻译： 公开了一种子宫内系统，用于以有控制和连续的速率长时间地将有益剂释放到子宫。 该系统的形状，尺寸和适用于插入和保留在子宫中。 该系统含有有益剂，并且由可通过扩散剂通过的共聚材料形成。 该材料是下列通式的乙烯 - 乙烯基酯聚合物：其中R是氢，2至7个碳原子的烷基或芳基，m是（4-80）重量％，n是（100-m） 重量％。

    Ocular insert
    2.
    发明授权
    Ocular insert 失效
    眼插入

    公开(公告)号：US3995635A

    公开(公告)日：1976-12-07

    申请号：US520277

    申请日：1974-11-04

    申请人： Takeru Higuchi ,  Anwar A. Hussain ,  John W. Shell

    发明人： Takeru Higuchi ,  Anwar A. Hussain ,  John W. Shell

    IPC分类号： A61F9/00 ,  A61K9/00 ,  A61K27/12 ,  A61M31/00

    CPC分类号： A61K9/0051 ,  A61F9/0017

    摘要： A drug-dispensing ocular insert containing a drug and suited for application to the eyeball to dispense said drug to the eye over a prolonged period of time, includes, for permitting facile insertion into and comfortable retention within the eye, and more importantly for preventing the accidental expulsion of the insert therefrom, first detent means adapted for insertion into the cul-de-sac of the conjunctiva between the sclera of the eyeball and the upper eyelid, and second, conjoint detent means, cooperative with said first detent means, adapted for insertion into the cul-de-sac of the conjunctiva between the said sclera of the eyeball and the lower eyelid.

    摘要翻译： 包含药物并且适用于眼球以将药物长时间分配给眼睛的药物分配眼部插入物包括用于允许容易地插入眼睛内并舒适地保持在眼睛内，并且更重要的是防止 插入物的意外排出，适于插入眼球巩膜与上眼睑之间的结膜死腔的第一止动装置，以及与所述第一制动装置配合的第二联合制动装置，适于 插入眼球的巩膜和下眼睑之间的结膜的死腔。

    Bioerodible ocular device
    3.
    发明授权
    Bioerodible ocular device 失效
    生物蚀刻眼睛装置

    公开(公告)号：US3981303A

    公开(公告)日：1976-09-21

    申请号：US600793

    申请日：1975-07-31

    申请人： Takeru Higuchi ,  Anwar A. Hussain ,  John W. Shell

    发明人： Takeru Higuchi ,  Anwar A. Hussain ,  John W. Shell

    IPC分类号： A61F9/00 ,  A61K9/00 ,  A61M31/00

    CPC分类号： A61K9/0051 ,  A61F9/0017

    摘要： An ocular insert for the continuous controlled administration of a predetermined therapeutically effective dosage of drug to the eye over a prolonged period of time. The device meters the flow of drug by means of a drug release rate controlling material. The insert bioerodes in the environment of the eye concurrently with the dispensing or at a point in time after the dispensing of the therapeutically desired amount of drug.

    摘要翻译： 用于在长时间内连续控制施用预定的治疗有效剂量的眼药物的眼部插入物。 该装置通过药物释放速率控制材料来衡量药物的流动。 在眼睛的环境中插入生物元件与分配或在分配治疗期望量的药物之后的时间点同时进行。

    Administration of alkaline earth metal salts of salicylamide
    4.
    发明授权
    Administration of alkaline earth metal salts of salicylamide 失效
    施用水杨酰胺的碱土金属盐

    公开(公告)号：US3956490A

    公开(公告)日：1976-05-11

    申请号：US557367

    申请日：1975-03-11

    申请人： Takeru Higuchi ,  Anwar A. Hussain

    发明人： Takeru Higuchi ,  Anwar A. Hussain

    IPC分类号： A61K31/60 ,  A61K31/615

    CPC分类号： A61K31/621 ,  A61K31/60

    摘要： Alkaline earth metal salts of salicylamide are administered in solid oral dosage forms with substantially improved analgesic, anti-inflammatory, antipyretic and sedative results as compared with salicylamide. Highest blood levels are obtained by administering enteric-coated salicylamide salt dosage forms.

    摘要翻译： 与水杨酰胺相比，水杨酰胺的碱土金属盐以固体口服剂型施用，具有显着改善的镇痛，抗炎，解热和镇静作用。 通过施用肠溶衣水杨酰胺盐剂型获得最高血液水平。

    Method of administration of sildenafil to produce instantaneous response for the treatment of erectile dysfunction
    8.
    发明授权
    Method of administration of sildenafil to produce instantaneous response for the treatment of erectile dysfunction 失效
    施用西地那非以治疗勃起功能障碍的瞬间反应的方法

    公开(公告)号：US06200591B1

    公开(公告)日：2001-03-13

    申请号：US09208439

    申请日：1998-12-10

    申请人： Anwar A. Hussain ,  Lewis W. Dittert

    发明人： Anwar A. Hussain ,  Lewis W. Dittert

    IPC分类号： A61F1302

    CPC分类号： A61K9/0043

    摘要： This invention provides a method of rapidly and reliably delivering sildenafil, or derivatives thereof, alone or in combination with other compounds, to the systemic circulation by administration via the nasal route so as to produce virtually instantaneous onset of beneficial effects in the treatment of erectile dysfunction. The present invention further provides pharmaceutical compositions comprising sildenafil, or derivatives thereof, and/or pharmaceutically acceptable salts thereof in a variety of unique pharmaceutical dosage forms, with and without apomorphine.

    摘要翻译： 本发明提供了一种通过经鼻途径给药而将西地那非或其衍生物单独或与其它化合物组合快速可靠地递送至全身循环的方法，从而在勃起功能障碍的治疗中产生几乎瞬间的有益效果 。 本发明进一步提供药物组合物，其包含西地那非或其衍生物，和/或其药学上可接受的盐，其具有和不含阿扑吗啡的各种独特的药物剂型。

    Method for enhanced brain delivery of bupropion
    9.
    发明授权
    Method for enhanced brain delivery of bupropion 失效
    增强安非他酮大脑输送的方法

    公开(公告)号：US6150420A

    公开(公告)日：2000-11-21

    申请号：US235833

    申请日：1999-01-22

    申请人： Abdulghani A. Houdi ,  Anwar A. Hussain

    发明人： Abdulghani A. Houdi ,  Anwar A. Hussain

    IPC分类号： A61K9/00 ,  A61K31/135

    CPC分类号： A61K9/0043 ,  A61K31/135

    摘要： This invention provides to a method for enhancement of delivery of bupropion by administration via the nasal route, and methods of treatment comprising intranasal administration of bupropion. The present invention further provides pharmaceutical compositions comprising bupropion and/or pharmaceutically acceptable salts thereof.

    摘要翻译： 本发明提供一种通过经鼻途径给药来增强安非他酮递送的方法，以及包括鼻内施用安非他酮的治疗方法。 本发明还提供包含安非他酮和/或其药学上可接受的盐的药物组合物。