公开(公告)号：US20110104247A1

公开(公告)日：2011-05-05

申请号：US12934361

申请日：2009-03-25

申请人： Takeshi Ito ,  Miho Ishigure

发明人： Takeshi Ito ,  Miho Ishigure

IPC分类号： A61K9/70 ,  A61K31/78 ,  A61P9/10

CPC分类号： A61K31/138 ,  A61K9/7061 ,  A61K9/7084

摘要： The present invention relates to a transdermally absorbable composition which is capable of retaining a β-blocker stably for a long period. More specifically, the present invention relates to a transdermally absorbable composition for stabilizing a β-blocker, which comprises a polymer compound having an amino group, a polyvalent carboxylic acid ester, a fatty acid ester and an acrylic polymer compound.

摘要翻译： 本发明涉及一种经皮吸收组合物，其能够长时间稳定地保持β-阻滞剂。 更具体地，本发明涉及一种用于稳定化合物的透皮吸收组合物，其包含具有氨基的聚合物化合物，多价羧酸酯，脂肪酸酯和丙烯酸类聚合物化合物。

公开(公告)号：US08974817B2

公开(公告)日：2015-03-10

申请号：US12934425

申请日：2009-03-25

申请人： Takeshi Ito ,  Miho Ishigure

发明人： Takeshi Ito ,  Miho Ishigure

IPC分类号： A61K9/70 ,  A61K9/00 ,  A61K31/16 ,  A61K31/19 ,  A61K31/138

CPC分类号： A61K31/138 ,  A61K9/7061 ,  A61K9/7084

摘要： Disclosed is a novel transdermally absorbable preparation which enables the efficient, stable and long-term administration of a drug to a living body. More specifically, the transdermally absorbable preparation comprises: a laminate comprising an outer film, a drug-containing layer and a support layer laminated in this order from the side to be contacted with the skin; and a fixing means for fixing the laminate on the skin. In the transdermally absorbable preparation, the outer film is a drug-permeable polymer film that can control the release of the drug into the skin and is provided as a surface of the laminate which is to be contact with the skin.

摘要翻译： 公开了一种新颖的经皮吸收制剂，其能够有效，稳定和长期地给予生物体药物。 更具体地，透皮吸收制剂包括：层压体，其包含从皮肤接触侧起依次层叠的外膜，药物含有层和支撑层; 以及用于将层压体固定在皮肤上的固定装置。 在透皮吸收制剂中，外膜是可以控制药物释放到皮肤中的药物可透过的聚合物膜，并且作为与皮肤接触的层压体的表面提供。

公开(公告)号：US20110104215A1

公开(公告)日：2011-05-05

申请号：US12934425

申请日：2009-03-25

申请人： Takeshi Ito ,  Miho Ishigure

发明人： Takeshi Ito ,  Miho Ishigure

IPC分类号： A61K9/70 ,  A61K31/138 ,  A61P9/00 ,  A61K31/192 ,  A61P29/00

CPC分类号： A61K31/138 ,  A61K9/7061 ,  A61K9/7084

摘要： Disclosed is a novel transdermally absorbable preparation which enables the efficient, stable and long-term administration of a drug to a living body. More specifically, the transdermally absorbable preparation comprises: a laminate comprising an outer film, a drug-containing layer and a support layer laminated in this order from the side to be contacted with the skin; and a fixing means for fixing the laminate on the skin. In the transdermally absorbable preparation, the outer film is a drug-permeable polymer film that can control the release of the drug into the skin and is provided as a surface of the laminate which is to be contact with the skin.

摘要翻译： 公开了一种新颖的经皮吸收制剂，其能够有效，稳定和长期地给予生物体药物。 更具体地，透皮吸收制剂包括：层压体，其包含从皮肤接触侧起依次层叠的外膜，药物含有层和支撑层; 以及用于将层压体固定在皮肤上的固定装置。 在透皮吸收制剂中，外膜是可以控制药物释放到皮肤中的药物可透过的聚合物膜，并且作为与皮肤接触的层压体的表面提供。

公开(公告)号：US20130164495A1

公开(公告)日：2013-06-27

申请号：US13809549

申请日：2011-07-11

申请人： Hideo Isoda ,  Hiroyuki Sakamoto ,  Takashi Koida ,  Hiroyasu Sakaguchi ,  Sadanobu Shirai ,  Masahiro Inazuki ,  Miho Ishigure

发明人： Hideo Isoda ,  Hiroyuki Sakamoto ,  Takashi Koida ,  Hiroyasu Sakaguchi ,  Sadanobu Shirai ,  Masahiro Inazuki ,  Miho Ishigure

IPC分类号： A61K9/70

CPC分类号： A61K9/703 ,  A61K9/70 ,  Y10T428/24322

摘要： The present invention relates to a backing for a water-based patch consisting of the following constituents, wherein the backing is excellent in pasty preparation retention and moisture retention, improves the persistence of drug efficacy by inhibiting the sublimation of the drug, gives neither restrained feeling nor rough feeling due to a thin thickness and an excellent elasticity, controls the moisture permeability, gives almost no sticky feeling and thereby gives an excellent feeling in application. A patch backing for a water-based pasty preparation consisting of a laminate, wherein the laminate consists of three layers, a film layer having through-holes is laminated between a nonwoven fabric layer A and a nonwoven fabric layer B, said film layer consists of a resin containing an olefin elastomer, the through-hole area per a hole is 0.02-0.18 mm2, and the opening ratio of the through-hole is 1-10%.

摘要翻译： 本发明涉及一种由以下成分构成的水性贴剂的背衬，其中，背衬具有优异的糊状制剂保持性和保湿性，通过抑制药物升华改善药物功效的持久性，既不抑制药物的抑制作用 由于薄的厚度和优异的弹性，也不会产生粗糙的感觉，控制透湿性，几乎不产生粘性，从而给人以极好的使用感。 一种由层压板构成的水性糊状制剂的贴剂背衬，其中层压体由三层构成，在无纺布层A和无纺布层B之间层叠具有通孔的膜层，所述膜层由 含有烯烃弹性体的树脂，每个孔的通孔面积为0.02〜0.18mm 2，通孔的开口率为1-10％。

公开(公告)号：US09884030B2

公开(公告)日：2018-02-06

申请号：US13809549

申请日：2011-07-11

申请人： Hideo Isoda ,  Hiroyuki Sakamoto ,  Takashi Koida ,  Hiroyasu Sakaguchi ,  Sadanobu Shirai ,  Masahiro Inazuki ,  Miho Ishigure

发明人： Hideo Isoda ,  Hiroyuki Sakamoto ,  Takashi Koida ,  Hiroyasu Sakaguchi ,  Sadanobu Shirai ,  Masahiro Inazuki ,  Miho Ishigure

IPC分类号： A61K9/70 ,  B32B3/26 ,  B32B5/22

CPC分类号： A61K9/703 ,  A61K9/70 ,  Y10T428/24322

摘要： The present invention relates to a backing for a water-based patch consisting of the following constituents, wherein the backing is excellent in pasty preparation retention and moisture retention, improves the persistence of drug efficacy by inhibiting the sublimation of the drug, gives neither restrained feeling nor rough feeling due to a thin thickness and an excellent elasticity, controls the moisture permeability, gives almost no sticky feeling and thereby gives an excellent feeling in application. A patch backing for a water-based pasty preparation consisting of a laminate, wherein the laminate consists of three layers, a film layer having through-holes is laminated between a nonwoven fabric layer A and a nonwoven fabric layer B, said film layer consists of a resin containing an olefin elastomer, the through-hole area per a hole is 0.02-0.18 mm2, and the opening ratio of the through-hole is 1-10%.

公开(公告)号：US20130138057A1

公开(公告)日：2013-05-30

申请号：US13807427

申请日：2011-07-11

申请人： Sadanobu Shirai ,  Masahiro Inazuki ,  Miho Ishigure ,  Hideo Isoda ,  Hiroyuki Sakamoto ,  Takashi Koida ,  Hiroyasu Sakaguchi

发明人： Sadanobu Shirai ,  Masahiro Inazuki ,  Miho Ishigure ,  Hideo Isoda ,  Hiroyuki Sakamoto ,  Takashi Koida ,  Hiroyasu Sakaguchi

IPC分类号： A61F13/02 ,  B32B3/26

摘要： The present invention relates to a backing having a three-layer structure prepared by sticking together an inner fiber layer for holding a pasty preparation, a film layer having through-holes, and an air-permeable outer fiber layer which prevents leaking out of the pasty preparation or a liquid component exuded from the pasty preparation, and also relates to an aqueous patch using the backing which can be applied for a long time.

摘要翻译： 本发明涉及一种背衬，其具有通过将用于保持糊状制剂的内纤维层粘合在一起而制成的三层结构，具有通孔的膜层和防止从糊状物渗出的透气性外纤维层 制剂或从糊状制剂中渗出的液体组分，并且还涉及使用可以长时间施用的背衬的水性贴剂。

公开(公告)号：US10583043B2

公开(公告)日：2020-03-10

申请号：US13807427

申请日：2011-07-11

申请人： Sadanobu Shirai ,  Masahiro Inazuki ,  Miho Ishigure ,  Hideo Isoda ,  Hiroyuki Sakamoto ,  Takashi Koida ,  Hiroyasu Sakaguchi

发明人： Sadanobu Shirai ,  Masahiro Inazuki ,  Miho Ishigure ,  Hideo Isoda ,  Hiroyuki Sakamoto ,  Takashi Koida ,  Hiroyasu Sakaguchi

IPC分类号： A61F13/02 ,  A61K31/192 ,  A61K31/167 ,  A61K9/70 ,  B32B3/26

摘要： The present invention relates to a backing having a three-layer structure prepared by sticking together an inner fiber layer for holding a pasty preparation, a film layer having through-holes, and an air-permeable outer fiber layer which prevents leaking out of the pasty preparation or a liquid component exuded from the pasty preparation, and also relates to an aqueous patch using the backing which can be applied for a long time.