公开(公告)号：US08703954B2

公开(公告)日：2014-04-22

申请号：US13143130

申请日：2010-02-24

Applicant: Takuma Minamisono ,  Noritaka Kitazawa ,  Ikuo Kushida

Inventor： Takuma Minamisono ,  Noritaka Kitazawa ,  Ikuo Kushida

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: The present invention provides a crystal of a 1.5 D-tartrate of a compound represented by the formula (1) having an A production inhibitory effect, characterized in that the crystal has a diffraction peak at a diffraction angle (20.2) of 23.2 in powder X-ray diffractometry; a crystal of a disulfate of the compound of the formula (1), characterized in that the crystal has a diffraction peak at a diffraction angle (20.2) of 17.1 in powder X-ray diffractometry; various other salts of the compound of the formula (1); crystal polymorphs of these salts; and the like, which are expected to be used as drug substances.

Abstract translation: 本发明提供具有A生成抑制作用的式（1）表示的化合物的1.5酒石酸盐的晶体，其特征在于，所述晶体在粉末X中的衍射角（20.2）为23.2°的衍射峰 射线衍射; 式（1）化合物的二硫酸盐的结晶，其特征在于，在粉末X射线衍射中，晶体具有衍射角（20.2）为17.1°的衍射峰; 式（1）化合物的各种其它盐; 这些盐的晶体多晶型物; 等等，其预期用作药物物质。

公开(公告)号：US20110275822A1

公开(公告)日：2011-11-10

申请号：US13143130

申请日：2010-02-24

Applicant: Takuma Minamisono ,  Noritaka Kitazawa ,  Ikuo Kushida

Inventor： Takuma Minamisono ,  Noritaka Kitazawa ,  Ikuo Kushida

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: The present invention provides a crystal of a 1.5 D-tartrate of a compound represented by the formula (1) having an A production inhibitory effect, characterized in that the crystal has a diffraction peak at a diffraction angle (20.2) of 23.2 in powder X-ray diffractometry; a crystal of a disulfate of the compound of the formula (1), characterized in that the crystal has a diffraction peak at a diffraction angle (20.2) of 17.1 in powder X-ray diffractometry; various other salts of the compound of the formula (1); crystal polymorphs of these salts; and the like, which are expected to be used as drug substances.

Abstract translation: 本发明提供具有A生成抑制效果的式（1）表示的化合物的1.5酒石酸盐的晶体，其特征在于，所述晶体在粉末X中的衍射角（20.2°）为23.2°的衍射峰 射线衍射; 式（1）化合物的二硫酸盐的结晶，其特征在于，在粉末X射线衍射中，晶体具有衍射角（20.2）为17.1°的衍射峰; 式（1）化合物的各种其它盐; 这些盐的晶体多晶型物; 等等，其预期用作药物物质。

公开(公告)号：US08058444B2

公开(公告)日：2011-11-15

申请号：US12109959

申请日：2008-04-25

Applicant: Jun Niijima ,  Kazutaka Nakamoto ,  Masayuki Matsukura ,  Keigo Tanaka ,  Eiichi Yamamoto ,  Takuma Minamisono

Inventor： Jun Niijima ,  Kazutaka Nakamoto ,  Masayuki Matsukura ,  Keigo Tanaka ,  Eiichi Yamamoto ,  Takuma Minamisono

IPC: C07D413/14

CPC classification number: C07D413/14

Abstract: There is provided a heterocycle-substituted pyridine derivative's salt or a crystal thereof. The present invention provides an acid addition salt of 3-(3-(4-(pyridin-2-yloxymethyl)-benzyl)-isoxazol-5-yl)-pyridin-2-yl amine or a crystal thereof as well as process for producing the same.

Abstract translation: 提供了杂环取代的吡啶衍生物的盐或其结晶。 本发明提供3-（3-（4-（吡啶-2-基氧基甲基） - 苄基） - 异恶唑-5-基） - 吡啶-2-基胺或其结晶的酸加成盐以及 生产相同。

公开(公告)号：US20080275244A1

公开(公告)日：2008-11-06

申请号：US12109959

申请日：2008-04-25

Applicant: Jun Niijima ,  Kazutaka Nakamoto ,  Masayuki Matsukura ,  Keigo Tanaka ,  Eiichi Yamamoto ,  Takuma Minamisono

Inventor： Jun Niijima ,  Kazutaka Nakamoto ,  Masayuki Matsukura ,  Keigo Tanaka ,  Eiichi Yamamoto ,  Takuma Minamisono

IPC: C07D213/02

CPC classification number: C07D413/14

Abstract: There is provided a heterocycle-substituted pyridine derivative's salt or a crystal thereof. The present invention provides an acid addition salt of 3-(3-(4-(pyridin-2-yloxymethyl)-benzyl)-isoxazol-5-yl)-pyridin-2-yl amine or a crystal thereof as well as process for producing the same.

Abstract translation: 提供了杂环取代的吡啶衍生物的盐或其结晶。 本发明提供3-（3-（4-（吡啶-2-基氧基甲基） - 苄基） - 异恶唑-5-基） - 吡啶-2-基胺或其结晶的酸加成盐以及 生产相同。