公开(公告)号：US10167248B2

公开(公告)日：2019-01-01

申请号：US14914744

申请日：2014-08-26

申请人： Taminco BVBA

发明人： Kristof Moonen ,  Bart Vandeputte ,  Daan Scheldeman ,  Kim Dumoleijn

IPC分类号： C07C229/00 ,  C07C209/26 ,  C07C209/36 ,  C07C249/04

摘要： Disclosed is a process for performing a chemical reaction selected from reductive amination and hydrogenation of a first functional group in an organic feed substrate, which feed substrate comprises at least one further functional group containing a halogen atom, wherein the halogen atom is selected from the list consisting of chlorine, bromine, iodine, and combinations thereof, in the presence of hydrogen and a heterogeneous catalyst comprising at least one metal from the list of Pd, Rh, and Ru, together with at least a second metal from the list consisting of Ag, Ni, Co, Sn, Cu and Au. The process is preferably applied for the reductive amination of 2-chloro-benzaldehyde to form 2-chloro-benzyldimethylamine, as an intermediate in the production of agrochemically active compounds and microbiocides of the methoximinophenylglyoxylic ester series. Further disclosed is a composition rich in 2-chloro-benzyldimethylamine, further comprising an amount of 2-chloro-benzyl alcohol and being low in chlorotoluene isomers.

公开(公告)号：US20160207874A1

公开(公告)日：2016-07-21

申请号：US14914744

申请日：2014-08-26

申请人： TAMINCO BVBA

发明人： Kristof Moonen ,  Bart Vandeputte ,  Daan Scheldeman ,  Kim Dumoleijn

IPC分类号： C07C209/26 ,  C07C249/04

CPC分类号： C07C209/26 ,  C07C209/365 ,  C07C249/04 ,  C07C211/52 ,  C07C251/48 ,  C07C211/29

摘要： Disclosed is a process for performing a chemical reaction selected from reductive amination and hydrogenation of a first functional group in an organic feed substrate, which feed substrate comprises at least one further functional group containing a halogen atom, wherein the halogen atom is selected from the list consisting of chlorine, bromine, iodine, and combinations thereof, in the presence of hydrogen and a heterogeneous catalyst comprising at least one metal from the list of Pd, Rh, and Ru, together with at least a second metal from the list consisting of Ag, Ni, Co, Sn, Cu and Au. The process is preferably applied for the reductive amination of 2-chloro-benzaldehyde to form 2-chloro-benzyldimethylamine, as an intermediate in the production of agrochemically active compounds and microbiocides of the methoximinophenylglyoxylic ester series. Further disclosed is a composition rich in 2-chloro-benzyldimethylamine, further comprising an amount of 2-chloro-benzyl alcohol and being low in chlorotoluene isomers.

摘要翻译： 公开了一种用于进行选自有机原料底物中的第一官能团的还原胺化和氢化的化学反应的方法，该进料底物包含至少一个含有卤素原子的另外的官能团，其中所述卤素原子选自列表 由氯，溴，碘及其组合组成，在氢存在下和包含来自Pd，Rh和Ru列表中的至少一种金属的非均相催化剂以及来自列表中的至少一种第二金属由Ag ，Ni，Co，Sn，Cu和Au。 该方法优选用于2-氯 - 苯甲醛的还原胺化以形成2-氯 - 苄基二甲胺，作为生产邻氨基苯基乙醛酸酯系列的农业化学活性化合物和杀微生物剂的中间体。 进一步公开的是富含2-氯 - 苄基二甲基胺的组合物，其还包含一定量的2-氯 - 苄基醇，并且氯代甲苯异构体低。

公开(公告)号：US10252979B2

公开(公告)日：2019-04-09

申请号：US15678183

申请日：2017-08-16

申请人： Taminco BVBA

发明人： Kristof Moonen ,  Bart Vandeputte ,  Daan Scheldeman ,  Kim Dumoleijn

IPC分类号： C07C209/26 ,  C07C209/36 ,  C07C249/04

摘要： Disclosed is a process for performing a chemical reaction selected from reductive amination and hydrogenation of a first functional group in an organic feed substrate, which feed substrate comprises at least one further functional group containing a halogen atom, wherein the halogen atom is selected from the list consisting of chlorine, bromine, iodine, and combinations thereof, in the presence of hydrogen and a heterogeneous catalyst comprising at least one metal from the list of Pd, Rh, and Ru, together with at least a second metal from the list consisting of Ag, Ni, Co, Sn, Cu and Au. The process is preferably applied for the reductive amination of 2-chloro-benzaldehyde to form 2-chloro-benzyldimethylamine, as an intermediate in the production of agrochemically active compounds and microbiocides of the methoximinophenylglyoxylic ester series. Further disclosed is a composition rich in 2-chloro-benzyldimethylamine, further comprising an amount of 2-chloro-benzyl alcohol and being low in chlorotoluene isomers.

公开(公告)号：US20170342019A1

公开(公告)日：2017-11-30

申请号：US15678183

申请日：2017-08-16

申请人： Taminco BVBA

发明人： Kristof Moonen ,  Bart Vandeputte ,  Daan Scheldeman ,  Kim Dumoleijn

IPC分类号： C07C209/26 ,  C07C249/04 ,  C07C209/36

CPC分类号： C07C209/26 ,  C07C209/365 ,  C07C249/04 ,  C07C211/52 ,  C07C251/48 ,  C07C211/29

摘要： Disclosed is a process for performing a chemical reaction selected from reductive amination and hydrogenation of a first functional group in an organic feed substrate, which feed substrate comprises at least one further functional group containing a halogen atom, wherein the halogen atom is selected from the list consisting of chlorine, bromine, iodine, and combinations thereof, in the presence of hydrogen and a heterogeneous catalyst comprising at least one metal from the list of Pd, Rh, and Ru, together with at least a second metal from the list consisting of Ag, Ni, Co, Sn, Cu and Au. The process is preferably applied for the reductive amination of 2-chloro-benzaldehyde to form 2-chloro-benzyldimethylamine, as an intermediate in the production of agrochemically active compounds and microbiocides of the methoximinophenylglyoxylic ester series. Further disclosed is a composition rich in 2-chloro-benzyldimethylamine, further comprising an amount of 2-chloro-benzyl alcohol and being low in chlorotoluene isomers.