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公开(公告)号：US11915792B2
公开(公告)日：2024-02-27
申请号：US17737106
申请日：2022-05-05
CPC分类号： G16B10/00 , G06F16/2228 , G16B30/10 , G16B40/20
摘要： This disclosure relates generally to a method and a system for profiling of metagenome samples. Most state of-art techniques for metagenomic profiling use homology-based, curated database of identified marker sequences generated after complex and costly pre-processing. The disclosed method and system for profiling of metagenome samples are a non-homology based, a non-marker based and an alignment free strain level profiling tools for microbe profiling. The disclosure works with a several k-mer based indexing techniques for constructing a compact and comprehensive multi-level indexing, wherein the multi-level indexing includes a L1-Index and a L2-Index. The multi-level indexing is used for profiling metagenomics by abundance estimation, wherein the abundance estimation includes a relative abundance and an absolute abundance.
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公开(公告)号：US20220392565A1
公开(公告)日：2022-12-08
申请号：US17737106
申请日：2022-05-05
摘要： This disclosure relates generally to a method and a system for profiling of metagenome samples. Most state of-art techniques for metagenomic profiling use homology-based, curated database of identified marker sequences generated after complex and costly pre-processing. The disclosed method and system for profiling of metagenome samples are a non-homology based, a non-marker based and an alignment free strain level profiling tools for microbe profiling. The disclosure works with a several k-mer based indexing techniques for constructing a compact and comprehensive multi-level indexing, wherein the multi-level indexing includes a L1-Index and a L2-Index. The multi-level indexing is used for profiling metagenomics by abundance estimation, wherein the abundance estimation includes a relative abundance and an absolute abundance.
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