公开(公告)号：US10962555B2

公开(公告)日：2021-03-30

申请号：US16068738

申请日：2017-01-06

Applicant: Temple University—Of The Commonwealth System of Higher Education

Inventor： Laura Goetzl ,  Edward Goetzl

IPC: G01N33/68 ,  C12Q1/6883

Abstract: The present invention provides for the first time the identification of fetal neural exosomal biomarkers isolated from maternal plasma useful in diagnosing fetal neurodevelopmental outcomes. The invention also provides the identification of neonatal neural exosomal biomarkers isolated from neonatal plasma useful in diagnosing neonatal neurodevelopmental outcomes The present invention therefore provides methods, kits and systems for diagnosing fetal neurodevelopmental outcomes, by examining relevant proteins and RNA in fetal neural exosomes isolated from a maternal plasma and neonatal neural exosomes isolated from neonatal plasma.

公开(公告)号：US20190025329A1

公开(公告)日：2019-01-24

申请号：US16068738

申请日：2017-01-06

Applicant: Temple University-Of The Commonwealth System of Higher Education

Inventor： Laura Goetzl ,  Edward Goetzl

IPC: G01N33/68 ,  C12Q1/6883

Abstract: The present invention provides for the first time the identification of fetal neural exosomal biomarkers isolated from maternal plasma useful in diagnosing fetal neurodevelopmental outcomes. The invention also provides the identification of neonatal neural exosomal biomarkers isolated from neonatal plasma useful in diagnosing neonatal neurodevelopmental outcomes The present invention therefore provides methods, kits and systems for diagnosing fetal neurodevelopmental outcomes, by examining relevant proteins and RNA in fetal neural exosomes isolated from a maternal plasma and neonatal neural exosomes isolated from neonatal plasma.