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公开(公告)号：US5260306A
公开(公告)日：1993-11-09
申请号：US727322
申请日：1991-07-02
CPC分类号： A61K9/0075 , A61K31/47 , A61K9/1688 , Y10S514/826 , Y10S514/951
摘要： There is described finely divided nedocromil sodium, comprising a therapeutically effective proportion of individual particles capable of penetrating deep into the lung, characterized in that a bulk of the particles which is both unaggolomerated and unmixed with a coarse carrier, is sufficiently free flowing to be filled into capsules on an automatic filling machine and to empty from an opened capsule in an inhalation device.There is also described a method of making the fine particles and pharmaceutical formulations containing them.
摘要翻译： 描述了细分的奈多罗米钠，其包含能够深入肺部的治疗有效比例的单个颗粒，其特征在于，大部分未粗调和未与粗制载体混合的颗粒的体积足够自由地流动以被填充 在自动灌装机中的胶囊中，并从吸入装置中的打开的胶囊中排空。 还描述了制备含有它们的细颗粒和药物制剂的方法。
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公开(公告)号：US4590206A
公开(公告)日：1986-05-20
申请号：US606542
申请日：1984-05-03
CPC分类号： A61K9/0075 , A61K9/1688 , Y10S514/826 , Y10S514/951
摘要： There is described a finely divided inhalation drug, e.g. sodium cromoglycate, comprising a therapeutically effective proportion of individual particles capable of penetrating deep into the lung, characterized in that a bulk of the particles which is both unagglomerated and unmixed with a coarse carrier, is sufficiently free flowing to be filled into capsules on an automatic filling machine and to empty from an opened capsule in an inhalation device. A number of the individual drug particles have a spherical, collapsed spherical or ring doughnut shape.There is also described a method of making the fine particles and pharmaceutical formulations containing them.
摘要翻译： 描述了细分的吸入药物，例如， 色甘酸钠，其包含治疗有效比例的能够深入肺部的单个颗粒，其特征在于，将大部分未粗化和未混合的粗颗粒的颗粒充分自由流动以自动地填充到胶囊中 填充机器并在吸入装置中从打开的胶囊中排空。 许多单个药物颗粒具有球形，塌陷的球形或环状环形状。 还描述了制备含有它们的细颗粒和药物制剂的方法。
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