公开(公告)号：US07531676B2

公开(公告)日：2009-05-12

申请号：US11189133

申请日：2005-07-26

申请人： Michael Anthony William Eaton ,  Timothy John Norman ,  David Parker ,  Terence Seward Baker ,  Andrew Neil Charles Weir ,  Catherine Fiona Catterall

发明人： Michael Anthony William Eaton ,  Timothy John Norman ,  David Parker ,  Terence Seward Baker ,  Andrew Neil Charles Weir ,  Catherine Fiona Catterall

IPC分类号： C07C233/00

CPC分类号： A61K9/1272 ,  A61K31/225 ,  A61K31/685 ,  A61K47/543 ,  A61K47/6929 ,  C07C235/10 ,  C07C235/12 ,  C07C237/10 ,  C07C271/20

摘要： Bipolar lipids are described which are able to form complexes with polyanions. The lipids comprise a cationic head linked to a hydrophobic backbone and a hydrophilic tail and are capable of self assembly to form stable complexes in aqueous solutions. The lipids are of particular use for the delivery of bioactive substances such as nucleic acids to cells in vitro and especially in vivo.

摘要翻译： 描述了能够与聚阴离子形成复合物的双相脂质。 脂质包含连接到疏水骨架和亲水尾部的阳离子头，并且能够自组装以在水溶液中形成稳定的络合物。 脂质特别用于在体外，特别是体内将生物活性物质例如核酸递送至细胞。

公开(公告)号：US07718157B1

公开(公告)日：2010-05-18

申请号：US10049670

申请日：2000-08-16

申请人： Terence Seward Baker ,  Andrew Neil Charles Weir ,  Catherine Fiona Catterall ,  Michael Anthony William Eaton ,  Timothy John Norman ,  David Parker

发明人： Terence Seward Baker ,  Andrew Neil Charles Weir ,  Catherine Fiona Catterall ,  Michael Anthony William Eaton ,  Timothy John Norman ,  David Parker

IPC分类号： C01B31/02 ,  C09C1/48

CPC分类号： C12N15/87 ,  A61K47/6801 ,  A61K47/6849 ,  A61K47/6907 ,  A61K48/00

摘要： Targeted lipids and lipid particles are described which are assemblies of multipolar lipids, targeting molecules such as antibodies and polyanions. The lipids are of particular use for the delivery of bioactive substances such as nucleic acids to cells in vitro and especially in vivo.

摘要翻译： 描述了靶向脂质和脂质颗粒，其是多极脂质的组装体，靶向分子例如抗体和聚阴离子。 脂质特别用于在体外，特别是体内将生物活性物质例如核酸递送至细胞。

公开(公告)号：US06583301B1

公开(公告)日：2003-06-24

申请号：US09646766

申请日：2000-11-20

申请人： Michael Anthony William Eaton ,  Timothy John Norman ,  David Parker ,  Terence Seward Baker ,  Andrew Neil Charles Weir ,  Catherine Fiona Catterall

发明人： Michael Anthony William Eaton ,  Timothy John Norman ,  David Parker ,  Terence Seward Baker ,  Andrew Neil Charles Weir ,  Catherine Fiona Catterall

IPC分类号： C07C23100

CPC分类号： A61K9/1272 ,  A61K31/225 ,  A61K31/685 ,  A61K47/543 ,  A61K47/6929 ,  C07C235/10 ,  C07C235/12 ,  C07C237/10 ,  C07C271/20

摘要： Bipolar lipids are described which are able to form complexes with polyanions. The lipids comprise a cationic head linked to a hydrophobic backbone and a hydrophilic tail and are capable of self assembly to form stable complexes in aqueous solutions. The lipids are of particular use for the delivery of bioactive substances such as nucleic acids to cells in vitro and especially in vivo.