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公开(公告)号:US4440683A
公开(公告)日:1984-04-03
申请号:US338651
申请日:1982-01-11
申请人: Teruji Tsuji , Yoshio Hahashima , Mitsuru Yoshioka , Masayuki Narisada , Hiroshi Tanida , Taichiro Komeno , Wataru Nagata
发明人: Teruji Tsuji , Yoshio Hahashima , Mitsuru Yoshioka , Masayuki Narisada , Hiroshi Tanida , Taichiro Komeno , Wataru Nagata
IPC分类号: C07D205/095 , C07D501/08 , C07D501/10 , C07D501/20 , C07D501/59 , C07D205/08 , C07D401/12 , C07D403/04 , C07D405/12
CPC分类号: C07D205/095 , Y02P20/55
摘要: An intermediate represented by following formula for synthesizing 3-hydroxy-3-cephem compounds. ##STR1## wherein A and B each is a hydrogen or amine substituent; R is a hydrogen or thiol substituent; Nal is a halogen; X is a hydroxy or carboxy protecting group; the broken line between A and R shows that when R and B are hydrogens, and A is a carboxylic acyl, the substituents can be combined to form an azetidimethiazoline bicyclic ring; and the enamine derivatives thereof.
摘要翻译: 由3-羟基-3-头孢烯化合物合成的下式表示的中间体。 其中A和B各自为氢或胺取代基; R是氢或硫醇取代基; 纳尔是卤素; X是羟基或羧基保护基; A和R之间的虚线表明当R和B为氢时,A为羧酰基时,可以将取代基结合形成氮杂环丁二烯环二环; 及其烯胺衍生物。