公开(公告)号：US20190352373A1

公开(公告)日：2019-11-21

申请号：US16480391

申请日：2018-01-19

申请人： Tessa Therapeutics Pte. Ltd.

发明人： John Edward Connolly ,  Richard Hopkins ,  Yijie Philbert Ong ,  Sven Hans Petersen

IPC分类号： C07K14/71 ,  A61P35/00 ,  A61K35/17 ,  C12N15/85 ,  A61K47/54 ,  C07K14/725

摘要： A TGF-β decoy receptor comprising a TGF-β binding region and a lipid anchor region is disclosed. Also disclosed is a chimeric antigen receptor (CAR) comprising a TGF-β binding region. Also disclosed are compositions comprising, and methods using, the TGF-β decoy receptors and CARs.