公开(公告)号：US20090182149A1

公开(公告)日：2009-07-16

申请号：US12296902

申请日：2006-10-13

申请人： Tetsuya Kawahara ,  Hitoshi Harada ,  Hiroki Terauchi ,  Nobuhisa Watanabe ,  Masato Ueda ,  Atsushi Kamada ,  Sachiko Kikuchi ,  Hiroshi Ishihara ,  Koichi Koyama

发明人： Tetsuya Kawahara ,  Hitoshi Harada ,  Hiroki Terauchi ,  Nobuhisa Watanabe ,  Masato Ueda ,  Atsushi Kamada ,  Sachiko Kikuchi ,  Hiroshi Ishihara ,  Koichi Koyama

IPC分类号： C07D405/14

CPC分类号： C07D405/14

摘要： Salts of 2-[({4-[(2,2-dimethyl-1,3-dioxan-5-yl)methoxy]-3,5-dimethylpyridin-2-yl}methyl)sulfinyl]-1H-benzimidazole and their crystalline and amorphous forms.

摘要翻译： 2 - [（{4 - [（2,2-二甲基-1,3-二恶烷-5-基）甲氧基] -3,5-二甲基吡啶-2-基}甲基）亚磺酰基] -1H-苯并咪唑的盐及其 晶体和无定形形式。

公开(公告)号：US20090292120A1

公开(公告)日：2009-11-26

申请号：US12444039

申请日：2007-10-11

申请人： Masato Ueda ,  Daisuke Iida ,  Sachiko Kikuchi ,  Masaharu Gotoda

发明人： Masato Ueda ,  Daisuke Iida ,  Sachiko Kikuchi ,  Masaharu Gotoda

IPC分类号： C07D513/04 ,  C07D405/14

CPC分类号： C07D401/12 ,  C07D405/14 ,  C07D493/10 ,  C07D513/14 ,  C07D519/00

摘要： The present invention provides a compound that has superior gastric acid secretion inhibitory action, ample long-lasting gastric acid secretion inhibitory action, and is able to maintain intragastric pH at a high level for an extended period of time, making it useful as a therapeutic or prophylactic agent for diseases or symptoms caused by gastric acid, as well as an active form of this compound (form to which the compound is converted in the body following administration thereof) in the form of a compound represented by general formula (1a) (wherein R2 represents a group represented by formula (I) or the like, and R1, R3, W1 and X− are as defined in the description).

摘要翻译： 本发明提供了具有优异的胃酸分泌抑制作用，充足的持久胃酸分泌抑制作用的化合物，并且能够将胃内pH保持在高水平长时间，使其可用作治疗或 由胃酸引起的疾病或症状的预防剂，以及该化合物的活性形式（化合物在给药后在体内转化的形式）以通式（1a）表示的化合物的形式（其中 R2表示由式（I）等表示的基团，R1，R3，W1和X-如说明书中所定义）。

公开(公告)号：US20110009624A9

公开(公告)日：2011-01-13

申请号：US12444039

申请日：2007-10-11

申请人： Masato Ueda ,  Daisuke Iida ,  Sachiko Kikuchi ,  Masaharu Gotoda

发明人： Masato Ueda ,  Daisuke Iida ,  Sachiko Kikuchi ,  Masaharu Gotoda

IPC分类号： C07D513/04 ,  C07D405/14

CPC分类号： C07D401/12 ,  C07D405/14 ,  C07D493/10 ,  C07D513/14 ,  C07D519/00

摘要： The present invention provides a compound that has superior gastric acid secretion inhibitory action, ample long-lasting gastric acid secretion inhibitory action, and is able to maintain intragastric pH at a high level for an extended period of time, making it useful as a therapeutic or prophylactic agent for diseases or symptoms caused by gastric acid, as well as an active form of this compound (form to which the compound is converted in the body following administration thereof) in the form of a compound represented by general formula (1a) (wherein R2 represents a group represented by formula (I) or the like, and R1, R3, W1 and X− are as defined in the description).

摘要翻译： 本发明提供了具有优异的胃酸分泌抑制作用，充足的持久胃酸分泌抑制作用的化合物，并且能够将胃内pH保持在高水平长时间，使其可用作治疗或 由胃酸引起的疾病或症状的预防剂，以及该化合物的活性形式（化合物在给药后在体内转化的形式）以通式（1a）表示的化合物的形式（其中 R2表示由式（I）等表示的基团，R1，R3，W1和X-如说明书中所定义）。