公开(公告)号：US20220402875A1

公开(公告)日：2022-12-22

申请号：US17880577

申请日：2022-08-03

申请人： Teva Pharmaceutical Industries, Ltd.

发明人： Chiara Caramelli ,  Cesare Federico ,  Emanuele Gabellieri ,  Matteo Magnani ,  Iolanda Micco ,  Georg C. Terstappen

IPC分类号： C07D213/75 ,  C07D403/12 ,  C07D401/12 ,  C07D413/12 ,  C07D417/12 ,  C07D241/16 ,  C07D277/32 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14

摘要： The present invention relates to antagonists of the S1P3 receptor formula (A) as herein described and pharmaceutical compositions thereof. The compounds of formula (A) are useful in the preparation of a medicament, in particular for the treatment of Alzheimer's disease.

公开(公告)号：US11472772B2

公开(公告)日：2022-10-18

申请号：US16751472

申请日：2020-01-24

申请人： Teva Pharmaceutical Industries, Ltd.

发明人： Chiara Caramelli ,  Cesare Federico ,  Emanuele Gabellieri ,  Matteo Magnani ,  Iolanda Micco ,  Georg C. Terstappen

IPC分类号： C07D213/75 ,  C07D403/12 ,  C07D401/12 ,  C07D413/12 ,  C07D417/12 ,  C07D241/16 ,  C07D277/32 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14

摘要： The present invention relates to antagonists of the S1P3 receptor formula (A) as herein described and pharmaceutical compositions thereof. The compounds of formula (A) are useful in the preparation of a medicament, in particular for the treatment of Alzheimer's disease.

公开(公告)号：US20200157052A1

公开(公告)日：2020-05-21

申请号：US16751472

申请日：2020-01-24

申请人： Teva Pharmaceutical Industries, Ltd.

发明人： Chiara Caramelli ,  Cesare Federico ,  Emanuele Gabellieri ,  Matteo Magnani ,  Iolanda Micco ,  Georg C. Terstappen

IPC分类号： C07D213/75 ,  C07D403/12 ,  C07D401/12 ,  C07D413/12 ,  C07D417/12 ,  C07D241/16 ,  C07D277/32 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14

摘要： The present invention relates to antagonists of the S1P3 receptor formula (A) as herein described and pharmaceutical compositions thereof. The compounds of formula (A) are useful in the preparation of a medicament, in particular for the treatment of Alzheimer's disease.