公开(公告)号：US20220226511A1

公开(公告)日：2022-07-21

申请号：US17614638

申请日：2020-05-28

Applicant: The Board of Regents of The University of Texas System

Inventor： Jinming GAO ,  Baran SUMER ,  Tian ZHAO ,  Zachary T. BENNETT

IPC: A61K49/00 ,  A61K9/107 ,  C08G81/02

Abstract: Described herein are pH responsive compounds, micelles, and compositions useful for the detection of primary and metastatic tumor tissues. Compounds described herein are imaging agents useful for the detection of primary and metastatic tumor tissue (including lymph nodes). Real-time fluorescence imaging during surgery aids surgeon in the detection of metastatic lymph nodes or delineate tumor tissue versus normal tissue, with the goal of achieving negative margins and complete tumor resection.