公开(公告)号：US20040229829A1

公开(公告)日：2004-11-18

申请号：US10723354

申请日：2003-11-25

Applicant: The Board of Regents of the University of Nebraska

Inventor： Patrick L. Iversen

IPC: A61K048/00

CPC classification number: C12N15/1137 ,  A61K31/337 ,  A61K38/00 ,  C12N2310/314 ,  C12N2310/3233 ,  A61K2300/00

Abstract: A method is described for improving the pharmacokinetics of a drug in a subject, by co-administering oligomers, preferably PMO's (phosphorodiamidate morpholino oligonucleotides), antisense to RNAs encoding drug-metabolizing enzymes, particularly p450 enzymes. The oligomers reduce production of the drug-metabolizing enzymes, which extends drug half-life and effectiveness and/or decreases drug toxicity.

公开(公告)号：US20040013662A1

公开(公告)日：2004-01-22

申请号：US10355388

申请日：2003-01-31

Applicant: The Board of Regents of the University of Nebraska

Inventor： Thomas R. Porter ,  Patrick L. Iversen

IPC: A61K038/47 ,  A61K038/42 ,  A61K038/38

CPC classification number: A61K41/0028 ,  A61K47/6925 ,  A61K49/223

Abstract: The invention relates to a new and improved pharmaceutical composition and method for delivery of therapeutic agents. The methods and composition of the invention can be used with several therapeutic agents and can achieve site specific delivery of a therapeutic or diagnostic substance. This can allow for lower doses and for improved efficacy with drugs which traditionally reach targeted sites and can result in improved utility for agents such as oligonucleotides and polynucleotides which are plagued with problems with biodistribution.

Abstract translation: 本发明涉及用于递送治疗剂的新的和改进的药物组合物和方法。 本发明的方法和组合物可以与几种治疗剂一起使用，并且可以实现治疗或诊断物质的位点特异性递送。 这可以允许较低剂量和用于改善传统上达到目标部位的药物的功效，并且可以导致药物如寡核苷酸和多核苷酸的改善效用，这些药物被困扰生物分布的问题。

公开(公告)号：US20040057946A1

公开(公告)日：2004-03-25

申请号：US10668448

申请日：2003-09-22

Applicant: The Board of Regents of the University of Nebraska

Inventor： Thomas R. Porter ,  Patrick L. Iversen

IPC: A61K038/46 ,  A61K038/40

CPC classification number: A61K41/0028 ,  A61K47/6925 ,  A61K49/223

Abstract: The invention relates to a new and improved pharmaceutical composition and method for delivery of therapeutic agents. The methods and composition of the invention can be used with several therapeutic agents and can achieve site specific delivery of a therapeutic or diagnostic substance. This can allow for lower doses and for improved efficacy with drugs which traditionally reach targeted sites and can result in improved utility for agents such as oligonucleotides and polynucleotides which are plagued with problems with biodistribution.

Abstract translation: 本发明涉及用于递送治疗剂的新的和改进的药物组合物和方法。 本发明的方法和组合物可以与几种治疗剂一起使用，并且可以实现治疗或诊断物质的位点特异性递送。 这可以允许较低剂量和用于改善传统上达到目标部位的药物的功效，并且可以导致药物如寡核苷酸和多核苷酸的改善效用，这些药物受到生物分布问题的困扰。