公开(公告)号：US11655307B2

公开(公告)日：2023-05-23

申请号：US16617074

申请日：2018-05-30

申请人： The Board of Regents of the University of Oklahoma

发明人： Courtney W. Houchen ,  Nathaniel Weygant ,  Dongfeng Qu ,  Randal May ,  Parthasarathy Chandrakesan ,  William L. Berry

IPC分类号： A61P35/00 ,  A61K47/68 ,  A61K39/00 ,  C07K16/40

CPC分类号： C07K16/40 ,  A61K47/6871 ,  A61P35/00 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/92

摘要： Antibodies and antigen-binding fragments thereof that specifically bind to human DCLK1 protein, hybridomas or other cell lines which express such antibodies and antigen-binding fragments thereof, nucleic acids, vectors, and host cells comprising nucleic acids which encode such antibodies and antigen-binding fragments thereof, and methods of use thereof are disclosed. In at least certain non-limiting embodiments, the antibodies or antigen-binding fragments thereof specifically bind to an epitope within isoform 2 or 4 of DCLK1 protein.

公开(公告)号：US09663585B2

公开(公告)日：2017-05-30

申请号：US14073169

申请日：2013-11-06

申请人： The Board of Regents of the University of Oklahoma

发明人： Courtney Houchen ,  Sripathi M. Sureban ,  Randal May ,  Dongfeng Qu ,  Nathaniel Weygant

IPC分类号： A61K6/00 ,  A61K39/00 ,  A61K39/395 ,  A61K45/00 ,  A61K45/06 ,  A61K47/00 ,  A61K47/48 ,  C07K16/40 ,  A61K9/127 ,  A61K31/7088 ,  C12N5/095 ,  C12N15/113 ,  C07K16/30

CPC分类号： C07K16/40 ,  A61K9/127 ,  A61K31/7088 ,  A61K45/06 ,  A61K47/6871 ,  A61K2039/505 ,  C07K16/30 ,  C07K2317/73 ,  C07K2317/76 ,  C12N5/0695 ,  C12N15/113 ,  C12N2310/14 ,  C12N2503/02 ,  C12N2510/00 ,  G01N2333/91215

摘要： Monoclonal antibodies against DCLK1 and conjugates containing these monoclonal antibodies are disclosed. Methods of producing and using these monoclonal antibodies are also disclosed.

公开(公告)号：US20140056972A1

公开(公告)日：2014-02-27

申请号：US14073169

申请日：2013-11-06

申请人： The Board of Regents of the University of Oklahoma

发明人： Courtney Houchen ,  Sripathi M. Sureban ,  Randal May ,  Dongfeng Qu ,  Nathaniel Weygant

IPC分类号： C07K16/40 ,  A61K45/06 ,  A61K39/395 ,  A61K9/127 ,  A61K47/48

CPC分类号： C07K16/40 ,  A61K9/127 ,  A61K31/7088 ,  A61K45/06 ,  A61K47/6871 ,  A61K2039/505 ,  C07K16/30 ,  C07K2317/73 ,  C07K2317/76 ,  C12N5/0695 ,  C12N15/113 ,  C12N2310/14 ,  C12N2503/02 ,  C12N2510/00 ,  G01N2333/91215

摘要： Monoclonal antibodies against DCLK1 and conjugates containing these monoclonal antibodies are disclosed. Methods of producing and using these monoclonal antibodies are also disclosed.

摘要翻译： 公开了针对DCLK1的单克隆抗体和含有这些单克隆抗体的缀合物。 还公开了生产和使用这些单克隆抗体的方法。