公开(公告)号：US20190031640A1

公开(公告)日：2019-01-31

申请号：US16026340

申请日：2018-07-03

Applicant: The Board of Regents of the University of Texas System

Inventor： Andre F. MARTINS ,  Sara CHIRAYIL ,  Maria Veroncia Clavijo JORDAN ,  A. Dean SHERRY

IPC: C07D401/14 ,  A61K49/10 ,  C07F5/00 ,  A61B5/055 ,  A61B5/00 ,  G01R33/56

Abstract: In some aspects, the present disclosure provides gadolinium based sensors which may be used to image zinc ions in vivo. In some embodiments, the compounds show appropriate reactivity with zinc ions while maintaining high relaxivity to achieve improved background relative to other sensors.