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公开(公告)号：US20180015030A1
公开(公告)日：2018-01-18
申请号：US15585980
申请日：2017-05-03
Inventor： Christopher C. CAPELLI , Phillip C. PHAN , Allen W. BURTON
Abstract: The present invention provides methods for reducing pain in a subject in need of such pain reduction by delivering, e.g., intrathecally or epidurally, a volatile anesthetic dissolved in a solution comprising an extractive solvent, e.g., DMSO or NMP, in an amount effective to reduce pain. Chronic or acute pain may be treated, or the anesthetic may be delivered as a regional anesthesia to a subject to anesthetize a portion the subject prior to a surgery. In certain embodiments, isoflurane, halothane, enflurane, sevoflurane, desflurane, methoxyflurane, or mixtures thereof may be used. Dosing regimens including a one-time administration, continuous and/or periodic administration are contemplated.
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2.发明申请公开(公告)号：US20200253864A1
公开(公告)日：2020-08-13
申请号：US16558962
申请日：2019-09-03
Inventor： Christopher C. CAPELLI , Phillip C. PHAN , Allen W. BURTON
IPC: A61K9/00 , A61K47/10 , A61P23/02 , A61K47/18 , A61K9/08 , A61K47/22 , A61K47/20 , A61K31/08 , A61K31/02
Abstract: The present invention provides methods for reducing pain in a subject in need of such pain reduction by delivering, e.g., intrathecally or epidurally, a volatile anesthetic dissolved in a solution comprising an extractive solvent, e.g., DMSO or NMP, in an amount effective to reduce pain. Chronic or acute pain may be treated, or the anesthetic may be delivered as a regional anesthesia to a subject to anesthetize a portion the subject prior to a surgery. In certain embodiments, isoflurane, halothane, enflurane, sevoflurane, desflurane, methoxyflurane, or mixtures thereof may be used. Dosing regimens including a one-time administration, continuous and/or periodic administration are contemplated.
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