公开(公告)号：US20220306584A1

公开(公告)日：2022-09-29

申请号：US17596816

申请日：2020-06-20

Applicant: The Board of Regents of the University of Texas System

Inventor： Jer-Tsong HSIEH ,  Jung-Mo AHN ,  Zhi-Ping LIU

IPC: C07D215/26 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  A61P35/00

Abstract: The present disclosure provides a new series of 8-hydroxyquinoline derivatives/analogs that are potent KDM4 inhibitors with high activity and selectivity against KDM4 enzymes. Also disclosed are the pharmaceutical compositions comprising such 8-hydroxyquinoline-based potent KDM4 inhibitors, or a pharmaceutically acceptable salt thereof, and method of use thereof, for treating cancer and neoplastic diseases and the like.