公开(公告)号：US20200025772A1

公开(公告)日：2020-01-23

申请号：US15658485

申请日：2017-07-25

申请人： The Board of Trustees of the University of Illinois

发明人： Andrew M. Smith ,  Chunlai Tu ,  Liang Ma

IPC分类号： G01N33/58 ,  G01N33/533 ,  C01B19/00 ,  C07K16/18 ,  C07K2/00 ,  G01N33/543

摘要： The present disclosure provides quantum dots and methods of making the quantum dots comprising a substantially homogeneous population of monomeric nanocrystals, of a very small size, about 7 nm to about 12 nm in diameter. The method comprises mixing a nanocrystal coated with weakly binding ligands or ions with a polymer in a solution and incubating at a temperature greater than about 100° C., thereby forming a quantum dot having a substantially homogenous population of monomeric nanocrystals. The quantum dots can be further conjugated to bioaffinity molecules, enabling broad utilization of compact, biofunctional quantum dots for studying crowded macromolecular environments.

公开(公告)号：US11226336B2

公开(公告)日：2022-01-18

申请号：US15658485

申请日：2017-07-25

申请人： The Board of Trustees of the University of Illinois

发明人： Andrew M. Smith ,  Chunlai Tu ,  Liang Ma

IPC分类号： G01N33/58 ,  G01N33/533 ,  B82Y15/00 ,  C07K2/00 ,  C01B19/00 ,  C07K16/18 ,  G01N33/543 ,  B82Y5/00 ,  B82Y40/00

摘要： The present disclosure provides quantum dots and methods of making the quantum dots comprising a substantially homogeneous population of monomeric nanocrystals, of a very small size, about 7 nm to about 12 nm in diameter. The method comprises mixing a nanocrystal coated with weakly binding ligands or ions with a polymer in a solution and incubating at a temperature greater than about 100° C., thereby forming a quantum dot having a substantially homogenous population of monomeric nanocrystals. The quantum dots can be further conjugated to bioaffinity molecules, enabling broad utilization of compact, biofunctional quantum dots for studying crowded macromolecular environments.