专利检索 ap:("The Charles Stark Draper Laboratory, Inc.") AND inv:"Hesham AZIZGOLSHANI" 第 1 页

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发明公开
INTEGRATED 3D CELL CULTURE MATRIX AND EPITHELIAL SUPPORT LAYER 审中-公开

公开(公告)号：US20230313104A1

公开(公告)日：2023-10-05

申请号：US18129344

申请日：2023-03-31

申请人： The Charles Stark Draper Laboratory, Inc.

发明人： Rebecca CHRISTIANSON , Elizabeth WIELLETTE , Melissa SPRACHMAN , Alicica M. MEEHAN-QIU , Lauren A. HAPACH , Peter HSI , Hesham AZIZGOLSHANI

IPC分类号： C12M1/12 , D01D5/00 , C12M3/00

CPC分类号： C12M25/14 , C12M25/02 , D01D5/0007 , C12M21/08 , D10B2321/12 , D10B2331/041

摘要： A method for generating a cell support interface for use in a three dimensional cell culture environment, may include electrospinning a mat having an epithelial support layer configured to create an intimate coupling between the epithelial cell and a porous matrix, including a first layer and a second layer, wherein the first layer is formed using a first solution at a first viscosity level and the second layer is formed using a second solution at a second viscosity level different from the first viscosity level.