公开(公告)号：US20220307034A1

公开(公告)日：2022-09-29

申请号：US17696510

申请日：2022-03-16

申请人： The Cleveland Clinic Foundation

发明人： Jianjun Zhao ,  Jianhong Lin

IPC分类号： C12N15/113 ,  A61K33/243 ,  A61K31/7056 ,  A61K31/506 ,  A61K31/454 ,  A61K31/519 ,  A61K31/549 ,  A61K31/381 ,  A61K31/085 ,  A61K31/427 ,  A61K31/4985 ,  A61K31/14 ,  A61K39/395 ,  A61K31/282 ,  A61P13/12

摘要： Provided herein are compositions, systems, articles of manufacture, and methods of treating a subject with: i) an APE2 inhibitor, and ii) a drug agent that causes increased expression of APE2 in said subject. In certain embodiments, the drug agent is Cisplatin or similar drug.