公开(公告)号：US20230016265A1

公开(公告)日：2023-01-19

申请号：US17770382

申请日：2020-10-28

Applicant: The Cleveland Clinic Foundation

Inventor： Steve Shih-lin Huang

IPC: A61K51/08 ,  A61P35/00

Abstract: A PSMA-specific agent comprising a compound according to Formula I or Formula II: wherein S1 is absent or is an organic spacer group comprising 3-10 carbons; A is an amino acid chain comprising 1 to 5 amino acids wherein at least one of the amino acids is selected from glutamic acid and aspartic acid; S2 is absent or is an organic spacer group comprising 1 to 15 carbons and/or 0 to 2 amino acids; I1 is an imaging group; and I2 is absent or is an imaging group. The PSMA-specific agents can be used to image PSMA within a tissue region and/or for the treatment of a cancer, such as prostate cancer.