专利检索 ap:("The Government of the United States of America, as represented by the Secretary of the Navy" OR "The Government of the United States of America, as represented by the Secretary, Department of Healt") AND inv:"Kirill Gorshkov" 第 1 页

1.

发明申请
Quantum Dot Conjugated Virus Spike Protein for Cell-Based Bio-Sensing Systems and Drug Screening 有权

公开(公告)号：US20220034884A1

公开(公告)日：2022-02-03

申请号：US17389645

申请日：2021-07-30

申请人： The Government of the United States of America, as represented by the Secretary of the Navy , The Government of the United States of America, as represented by the Secretary, Department of Healt

发明人： Eunkeu Oh , Kimihiro Susumu , Mason A. Wolak , Kirill Gorshkov

IPC分类号： G01N33/569 , G01N33/58

摘要： Quantum dots conjugated to SARS-CoV-2 Spike protein receptor binding domain (RBD) interact with gold nanoparticles bound to angiotensin converting enzyme 2 (ACE2) and thus undergo energy transfer. This energy transfer indicates RBD/ACE binding and can be used to assay for inhibitors thereof. Moreover, these labeled quantum dots were found to undergo endocytosis in cells expressing ACE2.