公开(公告)号：US20220306603A1

公开(公告)日：2022-09-29

申请号：US17596491

申请日：2020-06-12

申请人： The Governors of the University of Alberta

发明人： Frederick WEST ,  Jack TUSZYNSKI ,  Michael WEINFELD ,  Khaled Hassan BARAKAT ,  Ahmed H. ELMENOUFY ,  Francesco GENTILE ,  Feridoun KARIMI-BUSHERI ,  Claudia WEILBEER

IPC分类号： C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D471/04 ,  C07D413/14

摘要： The current application relates to pyronaridine or 6-chloro-2-methoxyacridine analogs having binding affinity for the ERCC1-XPF hetero-dimerization interface. The compounds can be used for targeting DNA repair in tumor cells via ER-CC1-XPF inhibition, therefore improving the therapeutic benefit of irradiation or other cancer treatment, or reducing the dosage and adverse effects associated with such treatment.