公开(公告)号：US11491174B2

公开(公告)日：2022-11-08

申请号：US16618845

申请日：2018-06-06

申请人： The Johns Hopkins University

发明人： Srinivasan Yegnasubramanian ,  William G. Nelson ,  Ajay Vaghasia ,  Philipp Nuhn

IPC分类号： A61K31/7068 ,  A61P35/00 ,  A61K31/203 ,  A61K31/4188 ,  A61K31/55

摘要： The disclosure generally relates to compositions and methods for the treatment of cancer. In some aspects, disclosed herein are methods for the induction of synthetic lethality with epigenetic therapy (ISLET) using a combination of at least one epigenetic compound and at least one chemotherapeutic agent. Also disclosed herein are screening methods for identifying compounds that induce killing of cancer cells when combined with at least one epigenetic compound. Further disclosed herein are methods of potentiating a therapeutic effect of a chemotherapeutic agent against a cancer, comprising administering to a subject having the cancer an epigenetic compound in an amount effective to potentiate the therapeutic effect of the chemotherapeutic agent against the cancer.

公开(公告)号：US20230100402A1

公开(公告)日：2023-03-30

申请号：US17946416

申请日：2022-09-16

申请人： The Johns Hopkins University

发明人： Srinivasan Yegnasubramanian ,  William G. Nelson ,  Ajay Vaghasia ,  Philipp Nuhn

IPC分类号： A61K31/7068 ,  A61P35/00 ,  A61K31/203 ,  A61K31/4188 ,  A61K31/55

摘要： The disclosure generally relates to compositions and methods for the treatment of cancer. In some aspects, disclosed herein are methods for the induction of synthetic lethality with epigenetic therapy (ISLET) using a combination of at least one epigenetic compound and at least one chemotherapeutic agent. Also disclosed herein are screening methods for identifying compounds that induce killing of cancer cells when combined with at least one epigenetic compound. Further disclosed herein are methods of potentiating a therapeutic effect of a chemotherapeutic agent against a cancer, comprising administering to a subject having the cancer an epigenetic compound in an amount effective to potentiate the therapeutic effect of the chemotherapeutic agent against the cancer.

公开(公告)号：US20210106603A1

公开(公告)日：2021-04-15

申请号：US16618845

申请日：2018-06-06

申请人： The Johns Hopkins University

发明人： Srinivasan Yegnasubramanian ,  William G. Nelson ,  Ajay Vaghasia ,  Philipp Nuhn

IPC分类号： A61K31/7068 ,  A61P35/00 ,  A61K31/55 ,  A61K31/203 ,  A61K31/4188

摘要： The disclosure generally relates to compositions and methods for the treatment of cancer. In some aspects, disclosed herein are methods for the induction of synthetic lethality with epigenetic therapy (ISLET) using a combination of at least one epigenetic compound and at least one chemotherapeutic agent. Also disclosed herein are screening methods for identifying compounds that induce killing of cancer cells when combined with at least one epigenetic compound. Further disclosed herein are methods of potentiating a therapeutic effect of a chemotherapeutic agent against a cancer, comprising administering to a subject having the cancer an epigenetic compound in an amount effective to potentiate the therapeutic effect of the chemotherapeutic agent against the cancer.