公开(公告)号：US20240189277A1

公开(公告)日：2024-06-13

申请号：US18554928

申请日：2022-04-14

申请人： The Johns Hopkins University

发明人： Laura Ensign ,  Justin Hanes ,  Yoo Chun Kim ,  Tung Heng Hsueh

IPC分类号： A61K31/404 ,  A61K9/00 ,  A61K31/192 ,  A61P27/02

CPC分类号： A61K31/404 ,  A61K9/0019 ,  A61K9/0048 ,  A61K31/192 ,  A61P27/02

摘要： Administration of therapeutic, prophylactic, or diagnostic agents that bind to a receptor or ligand in the eye or to the skin in microcrystalline form leads to increased delivery and long-lasting activity within the eye as compared with administration of the agent in non-crystalline form. Compositions and methods for delivery of active agents in microcrystalline form to the eye for the treatment, prevention and diagnosis of eye diseases and disorders are provided. In preferred embodiments, microcrystals include sunitinib malate in complex with pamoic acid. Administration of microcrystals of sunitinib malate/pamoic acid to the eye provides protection from glaucoma for up to 6 months or longer without retinal toxicity, following a single injection into the eye.