公开(公告)号：US10414801B2

公开(公告)日：2019-09-17

申请号：US15728282

申请日：2017-10-09

申请人： The Johns Hopkins University

发明人： Jun O. Liu ,  Jingxin Wang ,  Zufeng Guo ,  Wei Li ,  Shridhar Bhat ,  Manisha Das

IPC分类号： C07D471/04 ,  C07D498/14 ,  C07D515/04 ,  C07D515/14 ,  C07K7/64 ,  C07K17/08 ,  G01N33/566 ,  A61K31/436 ,  A61K31/4353 ,  C07D498/04

摘要： Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.

公开(公告)号：US20190389911A1

公开(公告)日：2019-12-26

申请号：US16563633

申请日：2019-09-06

申请人： The Johns Hopkins University

发明人： Jun O. Liu ,  Jingxin Wang ,  Zufeng Guo ,  Wei Li ,  Shridhar Bhat ,  Manisha Das

IPC分类号： C07K7/64 ,  C07K17/08 ,  C07D498/04 ,  C07D515/14 ,  C07D515/04 ,  C07D498/14 ,  G01N33/566 ,  C07D471/04 ,  A61K31/4353 ,  A61K31/436

摘要： Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.

公开(公告)号：US20180222942A1

公开(公告)日：2018-08-09

申请号：US15728282

申请日：2017-10-09

申请人： The Johns Hopkins University

发明人： Jun O. Liu ,  Jingxin Wang ,  Zufeng Guo ,  Wei Li ,  Shridhar Bhat ,  Manisha Das

IPC分类号： C07K7/64 ,  A61K31/436 ,  C07D471/04 ,  C07D498/04 ,  A61K31/4353 ,  C07D515/04 ,  C07D515/14 ,  C07K17/08 ,  G01N33/566 ,  C07D498/14

CPC分类号： C07K7/645 ,  A61K31/4353 ,  A61K31/436 ,  C07D471/04 ,  C07D498/04 ,  C07D498/14 ,  C07D515/04 ,  C07D515/14 ,  C07K17/08 ,  G01N33/566

摘要： Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.

公开(公告)号：US09783577B2

公开(公告)日：2017-10-10

申请号：US14987653

申请日：2016-01-04

申请人： The Johns Hopkins University

发明人： Jun O. Liu ,  Jingxin Wang ,  Zufeng Guo ,  Wei Li ,  Shridhar Bhat ,  Manisha Das

IPC分类号： C07K7/64 ,  A61K31/4353 ,  A61K31/436 ,  C07D471/04 ,  C07D498/04 ,  C07D498/14 ,  C07D515/04 ,  C07D515/14 ,  C07K17/08 ,  G01N33/566

CPC分类号： C07K7/645 ,  A61K31/4353 ,  A61K31/436 ,  C07D471/04 ,  C07D498/04 ,  C07D498/14 ,  C07D515/04 ,  C07D515/14 ,  C07K17/08 ,  G01N33/566

摘要： Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.

公开(公告)号：US20160115203A1

公开(公告)日：2016-04-28

申请号：US14987653

申请日：2016-01-04

申请人： The Johns Hopkins University

发明人： Jun O. Liu ,  Jingxin Wang ,  Zufeng Guo ,  Wei Li ,  Shridhar Bhat ,  Manisha Das

IPC分类号： C07K7/64 ,  G01N33/566

CPC分类号： C07K7/645 ,  A61K31/4353 ,  A61K31/436 ,  C07D471/04 ,  C07D498/04 ,  C07D498/14 ,  C07D515/04 ,  C07D515/14 ,  C07K17/08 ,  G01N33/566

摘要： Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.

摘要翻译： 提供了包含天然产物的已知蛋白质结合结构域的新型杂合环状文库。 还提供了使用部分分离的文库化合物制备这种文库和使用命中反卷积方法的合成方法。 这种方法适用于与整个人类蛋白质组一起使用以筛选结合和鉴定命中的这些文库。

公开(公告)号：US20210188914A1

公开(公告)日：2021-06-24

申请号：US17185658

申请日：2021-02-25

申请人： The Johns Hopkins University

发明人： Jun O. Liu ,  Jingxin Wang ,  Zufeng Guo ,  Wei Li ,  Shridhar Bhat ,  Manisha Das

IPC分类号： C07K7/64 ,  A61K31/4353 ,  A61K31/436 ,  C07D471/04 ,  C07D498/04 ,  C07D498/14 ,  C07D515/04 ,  C07D515/14 ,  C07K17/08 ,  G01N33/566

摘要： Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.

公开(公告)号：US10954273B2

公开(公告)日：2021-03-23

申请号：US16563633

申请日：2019-09-06

申请人： The Johns Hopkins University

发明人： Jun O. Liu ,  Jingxin Wang ,  Zufeng Guo ,  Wei Li ,  Shridhar Bhat ,  Manisha Das

IPC分类号： C07K7/64 ,  C07K17/08 ,  G01N33/566 ,  A61K31/436 ,  A61K31/4353 ,  C07D471/04 ,  C07D498/04 ,  C07D498/14 ,  C07D515/04 ,  C07D515/14

摘要： Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.