公开(公告)号：US20150050313A1

公开(公告)日：2015-02-19

申请号：US14458988

申请日：2014-08-13

申请人： The Regents of the University of California

发明人： Rock J. Mancini ,  Janine K. Tom ,  Aaron P. Esser-Kahn

IPC分类号： C07H21/04 ,  A61K31/80 ,  C08G65/335

CPC分类号： A61K31/80 ,  A61K47/549 ,  A61K47/55 ,  A61K47/64 ,  C08G65/329 ,  C08G65/331 ,  C08G65/3311 ,  C08G65/333 ,  C08G65/33303 ,  C08G65/33331 ,  C08G65/334 ,  C08G65/3342 ,  C08G65/3356 ,  C08G65/3358

摘要： Disclosed herein are heteromeric molecules comprising two or more different pathogen associated molecular patterns (PAMPs), wherein the two or more PAMPs are linked together with discrete, linear inter-PAMP spacing. Also disclosed are immunogenic compositions comprising the heteromeric molecules and related methods of stimulating an immune response in vivo in a subject or ex vivo comprising administering the immunogenic composition to cells. Also disclosed is a method of synthesizing an immunostimulant comprising: identifying 2 or more different PAMPS, covalently linking the 2 or more different PAMPS together, varying spacing between the 2 or more different PAMPs, and testing the effect of spacing between the 2 or more different PAMPS to identify an optimal spacing that results in immune stimulation.

摘要翻译： 本文公开了包含两种或更多种不同的病原体相关分子模式（PAMP）的异聚分子，其中两个或更多个PAMP通过离散的线性间隔间隔间隔连接在一起。 还公开了包含异源分子的免疫原性组合物和在受试者体内刺激免疫应答或离体的相关方法，包括向细胞施用免疫原性组合物。 还公开了合成免疫刺激剂的方法，其包括：鉴定2种或更多种不同的PAMPS，将2种或更多种不同PAMPS共价连接在一起，改变2种或更多种不同PAMP之间的间隔，并测试2种或更多种不同PAMP之间的间隔效应 PAMPS识别导致免疫刺激的最佳间距。