公开(公告)号：US20240286113A1

公开(公告)日：2024-08-29

申请号：US18655056

申请日：2024-05-03

Applicant: The Regents of the University of California

Inventor： Faik Tezcan ,  Jake Bailey ,  Ling Zhang

IPC: B01J20/26 ,  B01J20/24 ,  B01J20/28 ,  B01J20/34

CPC classification number: B01J20/261 ,  B01J20/24 ,  B01J20/28047 ,  B01J20/3425 ,  B01J20/345

Abstract: Hybrid materials are disclosed including molecular/protein crystals integrated with synthetic polymers. The disclosed materials combine the structural order and periodicity of crystals, the adaptiveness and tunable mechanical properties of polymeric networks, and the chemical versatility of protein building blocks. Some of the properties of the disclosed materials include the following: 1) allows crystals-which are typically rigid and brittle—to expand and contract reversibly; 2) incorporates polymers to increase the mechanical toughness of the crystals and allow self-healing; 3) reversibly expand/contract crystal lattices and mobilize the protein components therein may provide a new means to improve X-ray diffraction quality and explore otherwise inaccessible protein structural states using 3D protein crystallography; 4) creation of chemically and mechanically differentiated domains within single crystals. Some example embodiments combine the properties of hydrogels (flexibility, adaptability, elasticity, self-healing), crystals (structural order) and proteins (chemical and genetic tailorability).

公开(公告)号：US11975307B2

公开(公告)日：2024-05-07

申请号：US16763971

申请日：2018-11-13

Applicant: The Regents of the University of California

Inventor： Faik Tezcan ,  Jake Bailey ,  Ling Zhang

IPC: B01J20/26 ,  B01J20/24 ,  B01J20/28 ,  B01J20/34

CPC classification number: B01J20/261 ,  B01J20/24 ,  B01J20/28047 ,  B01J20/3425 ,  B01J20/345

Abstract: Hybrid materials are disclosed including molecular/protein crystals integrated with synthetic polymers. The disclosed materials combine the structural order and periodicity of crystals, the adaptiveness and tunable mechanical properties of polymeric networks, and the chemical versatility of protein building blocks. Some of the properties of the disclosed materials include the following: 1) allows crystals—which are typically rigid and brittle—to expand and contract reversibly; 2) incorporates polymers to increase the mechanical toughness of the crystals and allow self-healing; 3) reversibly expand/contract crystal lattices and mobilize the protein components therein may provide a new means to improve X-ray diffraction quality and explore otherwise inaccessible protein structural states using 3D protein crystallography; 4) creation of chemically and mechanically differentiated domains within single crystals. Some example embodiments combine the properties of hydrogels (flexibility, adaptability, elasticity, self-healing), crystals (structural order) and proteins (chemical and genetic tailorability).