公开(公告)号：US20220244263A1

公开(公告)日：2022-08-04

申请号：US17613881

申请日：2020-05-28

Applicant: The Regents of the University of California

Inventor： Thomas G. GRAEBER ,  Nikolas G. BALANIS ,  Katherine M. SHEU ,  Owen N. WITTE ,  Favour ESEDEBE ,  Jung Wook PARK

IPC: G01N33/574 ,  A61K45/06

Abstract: The current disclosure provides for methods of identifying and treating small cell neuroendocrine (SCN) tumors and small-round-blue cell tumor (SRBCT). Aspects of the disclosure relate to a method comprising measuring the level of expression of one or more biomarkers from Tables 1-3 in a biological sample from a cancer patient. Further aspects relate to a method for treating small cell neuroendocrine (SCN) cancer or small-round-blue cell tumor (SRBCT) in a patient comprising administering a cancer treatment to the patient, wherein the cancer treatment is a treatment selected from Table 4A, 4B, or combinations of treatments from Table 4A and/or 4B.