公开(公告)号：US20240327866A1

公开(公告)日：2024-10-03

申请号：US18579829

申请日：2022-07-21

申请人： The Regents of the University of California

发明人： Noriyuki Kasahara ,  Sara A. Collins ,  Alexander F. Haddad ,  Manish Aghi ,  Christopher Logg

IPC分类号： C12N15/86 ,  A61P35/00

CPC分类号： C12N15/86 ,  A61P35/00 ,  C12N2740/13043 ,  C12N2800/40 ,  C12N2820/002 ,  C12N2830/001

摘要： Provided herein are recombinant virus systems comprising two or more coordinatedly regulated viral vectors. Methods for treating a cell proliferative disorder using these systems are also provided. The compositions and methods provided herein provide more efficient and coordinated delivery of larger transgenes and/or larger quantities of a tansgene than previous methods by avoiding receptor interference and/or superinfection resistance, thereby enabling progressive replication of both vectors and efficient gene delivery by each vector.