公开(公告)号：US20240350422A1

公开(公告)日：2024-10-24

申请号：US18580090

申请日：2022-07-25

Applicant: The Regents of the University of California

Inventor： Nicole F. Steinmetz ,  Matthew D. Shin

IPC: A61K9/51 ,  A61K35/76

CPC classification number: A61K9/5184 ,  A61K9/5192 ,  A61K35/76

Abstract: Proteinaceous nanoparticles can be used to deliver large payloads of active ingredients, which is advantageous in medicine and agriculture. However, the conjugation of hydrophobic ligands to hydrophilic nanocarriers such as plant viral nanoparticles (plant VNPs) can result in aggregation by reducing overall solubility. Provided herein are improved methods for ligand conjugations, as well as the particles prepared by these methods. The disclosed methods promote efficient bioconjugation and prevent the aggregation that accompanies conventional bioconjugation methods, thus improving the stability, homogeneity, and translational potential of plant VNP conjugates in medicine and agriculture.