公开(公告)号：US20150175993A1

公开(公告)日：2015-06-25

申请号：US14406999

申请日：2013-06-20

申请人： The Regents of the University of California

发明人： Michael J. Heller ,  Tsukasa Takahashi ,  Michelle Lillian Cheung

IPC分类号： C12N9/50 ,  C12N13/00

CPC分类号： C12N9/50 ,  C07K7/06 ,  C07K7/08 ,  C12N13/00 ,  C12Y304/22 ,  G01N2333/95

摘要： Novel synthetic catalytic structures or “synzymes,” e.g., synthetic polypeptides, with catalytic properties are provided. It is believed that these synthetic catalytic structures mimic some of the precise conformational changes necessary for catalytic activities seen in enzymes. The catalytic properties of these synthetic catalytic structures or synzymes can be further improved by the application of controlled external forces, e.g., electric fields.

摘要翻译： 提供具有催化性质的新型合成催化结构或“合酶”，例如合成多肽。 据信这些合成催化结构模拟了在酶中看到的催化活性所需的一些精确的构象变化。 这些合成催化结构或合成酶的催化性能可以通过施加受控外力例如电场来进一步改善。

公开(公告)号：US09976133B2

公开(公告)日：2018-05-22

申请号：US14406999

申请日：2013-06-20

申请人： The Regents of the University of California

发明人： Michael J. Heller ,  Tsukasa Takahashi ,  Michelle Lillian Cheung

IPC分类号： C12N9/50 ,  C07K7/06 ,  C07K7/08 ,  C12N13/00

CPC分类号： C12N9/50 ,  C07K7/06 ,  C07K7/08 ,  C12N13/00 ,  C12Y304/22 ,  G01N2333/95

摘要： Novel synthetic catalytic structures or “synzymes,” e.g., synthetic polypeptides, with catalytic properties are provided. It is believed that these synthetic catalytic structures mimic some of the precise conformational changes necessary for catalytic activities seen in enzymes. The catalytic properties of these synthetic catalytic structures or synzymes can be further improved by the application of controlled external forces, e.g., electric fields.