Patent search ap:("The Regents of the University of California") AND inv:"Thomas Morton" Page 1

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发明申请
TARGETING TRANSFER RNA FOR THE SUPPRESSION OF NONSENSE MUTATIONS IN MESSENGER RNA 有权

公开(公告)号：US20230053353A1

公开(公告)日：2023-02-23

申请号：US17791498

申请日：2021-01-08

Applicant: The Regents of the University of California

Inventor： Prashant Mali , Dhruva Katrekar , Thomas Morton

IPC: C12N15/11 , C12N15/63 , C12N15/10

Abstract: The disclosure provides for a targeting transfer RNA (ttRNA) that that suppresses nonsense mutations in messenger RNA, that comprises an anticodon sequence that binds to a stop codon and a variable loop sequence that comprises an RNA aptamer that has strong binding affinity to an RNA binding protein; and methods of use thereof.

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