公开(公告)号：US20210346478A1

公开(公告)日：2021-11-11

申请号：US17232751

申请日：2021-04-16

申请人： The Regents of the University of Michigan

发明人： Duxin Sun ,  Ryan Clauson ,  Hongwei Chen ,  Chengyi Li ,  Wei Gao ,  Luke Bugada ,  Fei Wen ,  Brett Hill ,  Syed Monem Rizvi

IPC分类号： A61K39/00 ,  A61K47/02 ,  A61K9/16 ,  A61K38/19 ,  A61K47/69 ,  A61K47/64 ,  A61K45/06 ,  A61K39/295 ,  A61P35/00 ,  A61K39/39

摘要： The present invention provides, in some embodiments, methods, compositions, systems, and kits comprising nano-satellite complexes comprising: a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core; 3-25 satellite particles attached to, or absorbed to, said biocompatible coating; a plurality of antigenic peptides conjugated to, or absorbed to, said satellite particles; and at least one additional property. In other embodiments, provided herein are nano-satellite complexes comprising: a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core; a plurality of satellite particles attached to, or absorbed to, said biocompatible coating; a plurality of antigenic peptides conjugated to, or absorbed to, said satellite particles; and a plurality of LIGHT (TNFSF14) peptides conjugated to, or absorbed to, said satellite particles. In some embodiments, administration of the nanosatellite complexes to a subject with cancer achieves long-term cancer remission (e.g., when combined with an immune checkpoint inhibitor, such as αPD1).