专利检索 ap:("The Regents of the University of Mishigan") AND inv:"Szymon KLOSSOWSKI" 第 1 页

1.

发明公开
ASH1L INHIBITORS AND METHODS OF TREATMENT THEREWITH 审中-公开

公开(公告)号：US20240277856A1

公开(公告)日：2024-08-22

申请号：US18530017

申请日：2023-12-05

申请人： The Regents of the University of Mishigan

发明人： Jolanta GREMBECKA , Szymon KLOSSOWSKI , Jing DENG , Tomasz CIERPICKI , Hao LI , Hongzhi MIAO , Trupta PUROHIT , EunGi KIM

IPC分类号： A61K47/64 , A61K9/00 , A61K31/404 , A61K31/454 , A61K31/4545 , A61K38/45 , A61K47/54 , A61P35/02 , C07D209/24 , C07D471/04

CPC分类号： A61K47/64 , A61K9/0019 , A61K9/0053 , A61K31/404 , A61K31/454 , A61K31/4545 , A61K38/45 , A61K47/545 , A61K47/556 , A61P35/02 , C07D209/24 , C07D471/04 , C12Y203/02

摘要： Provided herein are small molecules that bind to ASH1L and inhibit ASH1L activity, and methods of use thereof for the treatment of disease, including acute leukemia, solid cancers and other diseases dependent on activity of ASH1L.