公开(公告)号：US20130101646A1

公开(公告)日：2013-04-25

申请号：US13705928

申请日：2012-12-05

申请人： The School of Pharmacy, University of London

发明人： Abdul Waseh Basit ,  Sudax Shina Murdan ,  Richard Andrew Kendall

IPC分类号： A61K9/14

CPC分类号： A61K9/14 ,  A61K9/1635 ,  A61K9/1694 ,  B01J13/02

摘要： A method of producing microparticles having a median diameter up to 100 μm and the microparticles so produced are described. The method includes the steps of providing a solvent having a bioactive dispersed or dissolved therein and a vehicle dissolved therein, carrying out an emulsification in a non-solvent phase to produce an emulsion containing the bioactive and the vehicle in a solvent phase, and evaporating the solvent to leave the microparticles, wherein a mixture of at least two surfactants is employed to stabilize the emulsion and wherein the mixture has a hydrophilic-lipophilic balance (HLB) of up to 8.

摘要翻译： 描述了具有高达100μm的中值粒径和如此制造的微粒的微粒的制造方法。 该方法包括以下步骤：提供溶解有生物活性的溶剂和溶解于其中的载体，在非溶剂相中进行乳化，以在溶剂相中生成含有生物活性剂和载体的乳液，并蒸发 溶剂以离开微粒，其中使用至少两种表面活性剂的混合物来稳定乳液，并且其中所述混合物具有高达8的亲水亲油平衡（HLB）。